| Titre : | Tracking of Serum 25-Hydroxyvitamin D Levels During 14 Years in a Population-based Study and During 12 Months in an Intervention Study. (2010) |
| Auteurs : | Rolf JORDE ; EMAUS (Nina) : NOR. Institute of Community Medicine. University of Tromso. Tromso. ; FIGENSCHAU (Yngve) : NOR. Diagnostic Clinic. Department of Medical Biochemistry. University Hospital of North Norway. Tromso. ; Guri GRIMNES ; Moira HUTCHINSON ; SNEVE (Monica) : NOR. Department of Ophthalmology and Neurosurgery. Division of Ophthalmology. University Hospital of North Norway. Tromso. ; Medical Clinic. Department of Endocrinology. University Hospital of North Norway. Tromso. NOR |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 171, n° 8, 2010) |
| Pagination : | 903-908 |
| Langues: | Anglais |
| Mots-clés : | Sérum ; Population ; Etude prospective ; Vitamine D |
| Résumé : | [BDSP. Notice produite par INIST-CNRS qpjCHR0x. Diffusion soumise à autorisation]. Low serum 25-hydroxyvitamin D (25 (OH) D) levels are associated with risk factors for cardiovascular disease, and they also appear to predict later development of type 2 diabetes, cancer, and an increased mortality rate. These predictions are all based on a single 25 (OH) D measurement, but so far there are no known reports on tracking of serum 25 (OH) D levels. In the present Norwegian study, serum 25 (OH) D levels were measured 1) in 2,668 subjects in the 1994 and 2008 Tromso surveys and 2) every third month for 1 year in 94 subjects randomly assigned to placebo in a vitamin D intervention study. There was a marked seasonal variation in 25 (OH) D, and, depending on the method of adjusting for season, the correlation coefficient between serum 25 (OH) D measurements from 1994 and 2008 ranged from 0.42 to 0.52. In the 1-year intervention study, the correlation between baseline and 12-month values was 0.80. Apart from the effect of season, changes in weight, intake of vitamin D, and physical activity were related to change in serum 25 (OH) D levels. Tracking of serum 25 (OH) D appears similar to that for blood pressure and serum lipids, and it provides some support for the use of a single 25 (OH) D measurement to predict future health outcomes. |
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