| Titre : | Prospective Associations of Insomnia Markers and Symptoms With Depression. (2010) |
| Auteurs : | SZKLO-COXE (Mariana) : USA. School of Community and Environmental Health. College of Health Sciences. Old Dominion University. Norfolk. VA. ; BENCA (Ruth-M) : USA. Department of Psychiatry. School of Medicine and Public Health. University of Wisconsin. Madison. WI. ; Laurel-A FINN ; Paul-E PEPPARD ; Terry YOUNG |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 171, n° 6, 2010) |
| Pagination : | 709-720 |
| Langues: | Anglais |
| Mots-clés : | Etat dépressif ; Etude prospective ; Association ; Symptôme ; Sommeil ; Initiation ; Maintenance ; Electrodiagnostic |
| Résumé : | [BDSP. Notice produite par INIST-CNRS o9n7R0xA. Diffusion soumise à autorisation]. Whether insomnia, a known correlate of depression, predicts depression longitudinally warrants elucidation. The authors examined 555 Wisconsin Sleep Cohort Study participants aged 33-71 years without baseline depression or antidepressant use who completed baseline and follow-up overnight polysomnography and had complete questionnaire-based data on insomnia and depression for 1998-2006. Using Poisson regression, they estimated relative risks for depression (Zung scale score>50) at 4-year (average) follow-up according to baseline insomnia symptoms and polysomnographic markers. Twenty-six participants (4.7%) developed depression by follow-up. Having 3-4 insomnia symptoms versus none predicted depression risk (age-sex-and comorbidity-adjusted relative risk (RR)=3.2,95% confidence interval : 1.1,9.6). After multiple adjustments, frequent difficulty falling asleep (RR=5.3,95% confidence interval : 1.1,27.9) and polysomnographically assessed (upper or lower quartiles) sleep latency, continuity, and duration (RRs=2.2-4.7 ; P's<0.05) predicted depression. Graded trends (P-trend<=0.05) were observed with increasing number of symptoms, difficulty falling asleep, and difficulty returning to sleep. Given the small number of events using Zung>50 (depression cutpoint), a limitation that may bias multivariable estimates, continuous depression scores were analyzed ; mean values were largely consistent with dichotomous findings. Insomnia symptoms or markers increased depression risk 2.2-to 5.3-fold. These results support prior findings based on self-reported insomnia and may extend similar conclusions to objective markers. Heightened recognition and treatment of insomnia may prevent subsequent depression. |
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