| Titre : | Biomarkers of Systemic Inflammation and Risk of Incident, Symptomatic Benign Prostatic Hyperplasia : Results From the Prostate Cancer Prevention Trial. (2010) |
| Auteurs : | Jeannette-M SCHENK ; Mario KRATZ ; Alan-R KRISTAL ; LIN (Daniel-W) : USA. Department of Urology. University of Washington. Seattle. WA. ; Marian-L NEUHOUSER ; Catherine-M TANGEN ; THOMPSON (Ian-M) : USA. Department of Urology. University of Texas Health Science Center at San Antonio. San Antonio. TX. ; Emily White |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 171, n° 5, 2010) |
| Pagination : | 571-582 |
| Langues: | Anglais |
| Mots-clés : | Obésité ; Inflammation ; Facteur risque ; Risque ; Incidence ; Symptôme ; Résultat ; Prévention santé ; Essai préventif ; Essai thérapeutique ; Procès ; Prostate ; Tumeur bénigne ; Cancer |
| Résumé : | [BDSP. Notice produite par INIST-CNRS s7m9R0xt. Diffusion soumise à autorisation]. The authors conducted a nested case-control study of serum inflammatory markers and risk of symptomatic benign prostatic hyperplasia (BPH), using data from the placebo arm of the Prostate Cancer Prevention Trial (1993-2003). Incident BPH (n=676) was defined as treatment, report of 2 International Prostate Symptom Score (IPSS) values>14, or 2 increases of>=5 from baseline values with at least one value>=12. Controls (n=683) were men who reported no BPH treatment or IPSS values>7 over the 7-year trial. Baseline serum was analyzed for C-reactive protein, tumor necrosis factor alpha (monomer), soluble tumor necrosis factor receptors I and II (sTNF-RI and sTNF-RII), interleukin 6, and interferon gamma. Controlled for age and race, a high C-reactive protein concentration was associated with increased BPH risk (for quartile 4 vs. quartile 1, odds ratio (OR)=1.40,95% confidence interval (CI) : 1.04,1.88) ; this was attenuated after control for body mass index (OR=1.30,95% CI : 0.95,1.75). Low sTNF-RII and high interleukin 6 concentrations were associated with increased BPH risk (for quartile 4 vs. quartile 1, sTNF-RII : OR=0.61,95% CI : 0.46,0.82 ; interleukin 6 : OR=1.79,95% CI : 1.32,2.42) ; these associations were only in men aged<65 years. Results suggest that systemic inflammation or lower levels of soluble receptors that bind inflammatory cytokines increase BPH risk. |
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