Titre : | Field Synopsis and Synthesis of Genetic Association Studies in Osteoarthritis : The CUMAGAS-OSTEO Information System. (2010) |
Auteurs : | Elias ZINTZARAS ; KARACHALIOS (Theofilos) : GRC. Department of Orthopedics. School of Medicine. University of Thessaly. Larissa. ; Georgios-D KITSIOS ; Paraskevi RODOPOULOU ; ZIOGAS (Dimitrios-C) : USA. Department of Gastroenterology. Beth Israel Deaconess Medical Center. Boston. MA. ; Center for Clinical Evidence Synthesis. Institute for Clinical Research and Health Policy Studies. Tufts Medical Center. Boston. MA. USA |
Type de document : | Article |
Dans : | American journal of epidemiology (vol. 171, n° 8, 2010) |
Pagination : | 851-858 |
Langues: | Anglais |
Mots-clés : | Arthrose ; Arthropathie ; Génétique ; Association ; Système information ; Epidémiologie ; Maladie dégénérative |
Résumé : | [BDSP. Notice produite par INIST-CNRS R0xCCkBA. Diffusion soumise à autorisation]. A comprehensive and systematic assessment of the current status of genetic association studies (GAS) for osteoarthritis was conducted. Data from 327 GAS involving 187 distinct genetic variants were analyzed and cataloged in CUMAGAS-OSTEO, a Web-based information system (biomath. med. uth. gr) that allows the retrieval and synthesis of data from GAS on osteoarthritis. In individual studies, 66 variants (mostly single nucleotide polymorphisms) showed significant associations with osteoarthritis risk. For 19 variants, the association was significant at P |