| Titre : | Pesticide Use and Thyroid Disease Among Women in the Agricultural Health Study. (2010) |
| Auteurs : | Whitney-S GOLDNER ; . FANG YU ; Jane-A HOPPIN ; Freya KAMEL ; Tricia-D LEVAN ; Dale-P SANDLER ; Epidemiology Branch. National Institute of Environmental Health Sciences. Research Triangle Park. North Carolina. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 171, n° 4, 2010) |
| Pagination : | 455-464 |
| Langues: | Anglais |
| Mots-clés : | Hyperthyroïdie ; Hypothyroïdie ; Pesticide ; Utilisation ; Femme ; Agriculture ; Santé environnementale ; Environnement ; Thyroïde ; Homme ; Glande endocrine [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST-CNRS ECknR0x8. Diffusion soumise à autorisation]. Thyroid disease is common, and evidence of an association between organochlorine exposure and thyroid disease is increasing. The authors examined the cross-sectional association between ever use of organochlorines and risk of hypothyroidism and hyperthyroidism among female spouses (n=16,529) in Iowa and North Carolina enrolled in the Agricultural Health Study in 1993-1997. They also assessed risk of thyroid disease in relation to ever use of herbicides, insecticides, fungicides, and fumigants. Prevalence of self-reported clinically diagnosed thyroid disease was 12.5%, and prevalence of hypothyroidism and hyperthyroidism was 6.9% and 2.1%, respectively. There was an increased odds of hypothyroidism with ever use of organochlorine insecticides (adjusted odds ratio (ORadj)=1.2 (95% confidence interval (CI) : 1.0,1.6) and fungicides (ORadj=1.4 (95% CI : 1.1,1.8) but no association with ever use of herbicides, fumigants, organophosphates, pyrethroids, or carbamates. Specifically, ever use of the organochlorine chlordane (ORadj=1.3 (95% CI : 0.99,1.7), the fungicides benomyl (ORadj=3.1 (95% CI : 1.9,5.1) and maneb/mancozeb (ORadj=2.2 (95% CI : 1.5,3.3), and the herbicide paraquat (ORadj=1.8 (95% CI : 1.1,2.8) was significantly associated with hypothyroidism. Maneb/mancozeb was the only pesticide associated with both hyperthyroidism (ORadj=2.3 (95% CI : 1.2,4.4) and hypothyroidism. These data support a role of organochlorines, in addition to fungicides, in the etiology of thyroid disease among female spouses enrolled in the Agricultural Health Study. |
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