| Titre : | Albuminuria as a marker of the risk of developing type 2 diabetes in non-diabetic Aboriginal Australians. (2006) |
| Auteurs : | . ZHIQIANG WANG ; Wendy-E HOY ; University of Queensland. Department of Medicine-Central Clinical Division. Centre for Chronic Disease. Brisbane Queensland. AUS |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 35, n° 5, 2006) |
| Pagination : | 1331-1335 |
| Langues: | Anglais |
| Mots-clés : | Facteur risque ; Epidémiologie ; Protéinurie ; Australie ; Océanie ; Enquête cas témoin ; Ethnie ; Homme ; Glande endocrine [pathologie] ; Métabolisme [pathologie] ; Appareil urinaire [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 1jR0xkCW. Diffusion soumise à autorisation]. Background : Aboriginal Australians experience a higher risk of diabetes than the general Australian population. In this paper, we conducted a nested case-control study to determine whether the presence of microalbuminuria and macroalbuminuria is associated with the development of diabetes among diabetes-free Aboriginal people at baseline. Methods : Urine albumin to creatinine ratios (ACRs) were obtained from 882 Aboriginal people aged 20-74 years from one community. Among them 750 were free of either clinical known diabetes or newly diagnosed diabetes according to WHO 1999 criteria. Over an 11 year follow-up period, 117 participants developed diabetes. They were defined as cases. Each case was matched by an individual control with same sex and body mass index (BMI) category, and age within 2 years. Conditional logistic regression was used to assess the association between albuminuria and diabetes. Results : The baseline level of ACR was significantly higher among cases than among controls. The odds ratios for future diabetes were 2.36 [95% confidence interval (95% CI) 1.01-5.50] and 3.27 (95% CI 1.38-7.77) for middle and upper tertiles, respectively, with adjustment for age, BMI, serum total cholesterol, serum C-reactive protein values, and fasting plasma glucose at the baseline. The adjusted odds ratios were 1.90 (95% CI 0.88-4.06) and 2.51 (95% CI 1.08-5.87) for those with microalbuminuria and macroalbuminuria, respectively. Conclusions : The presence of microalbuminuria and macroalbuminuria predicts diabetes independent of other known risk markers of development of type 2 diabetes in Aboriginal people. |
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