| Titre : | Surveillance of HIV and viral hepatitis by analysis of samples from drug related deaths. (2006) |
| Auteurs : | Peer-Brehm CHRISTENSEN ; Jytte BANNER ; Susan COWAN ; Jorgen GEORGSEN ; Kari GRASAASEN ; Gitte-Wulf JURGENSEN ; Birgitte KRINGSHOLM ; Court PEDERSEN ; Gabriela-Felicia STEIN ; Jorgen-L THOMSEN ; Odense University Hospital. Department of Infectious Diseases. Odense. DNK |
| Type de document : | Article |
| Dans : | European journal of epidemiology (vol. 21, n° 5, 2006) |
| Pagination : | 383-387 |
| Langues: | Anglais |
| Mots-clés : | Hépatite virale ; Virose ; Infection ; Surveillance ; Sida ; VIH ; Rétrovirus ; Virus ; Toxicomanie ; Danemark ; Europe ; Mortalité ; Dépistage ; Epidémiologie ; Toxicomane ; Homme ; Immunopathologie ; Appareil digestif [pathologie] ; Foie [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST-CNRS pR0xKn1T. Diffusion soumise à autorisation]. Objectives : To determine the prevalence of antibodies against HIV, hepatitis B (HBV) and hepatitis C (HCV) in postmortem samples from drug related deaths (DRDs) in Denmark. Design : Prospective cohort study. Postmortem samples tested for anti-HIV, anti-HCV anti-HBc and anti-HBs. Comparison to pre-mortem testing when possible. DRDs were searched for in the national register of drug treatment, national prison registers, and the national infectious disease register. Setting : National level. Participants : Drug related deaths admitted to Danish Institutes of Forensic Medicine during 2004. Main outcome measures : Prevalence of antibodies, injection drug use, drug treatment experience and prevalence of cirrhosis. Results : Samples for analysis were obtained from 78% (233/299) of DRDs. The prevalences of anti-HIV, anti-HCV and anti-HBc were 4% (9/214), 51% (110/215), and 35% (74/209), indicating a persisting low prevalence of HIV and a declining prevalence of HCV and HBV. Injecting ever was detected among 45% of DRDs and this was associated with a significantly higher prevalence of hepatitis B and C. Among the DRDs 56% received drug treatment and 12% had cirrhosis at autopsy. Evidence of vaccination against HBV was found among 16% (21/128). Conclusions : Monitoring of viral hepatitis and HIV among DRDs is feasible, and our survey indicates a falling prevalence among Danish drug users. Surveillance based on drug users in treatment may overestimate the true prevalence. |
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