| Titre : | Arsenic exposure from drinking water and risk of premalignant skin lesions in Bangladesh : Baseline results from the health effects of arsenic longitudinal study. (2006) |
| Auteurs : | AHSAN (Habibul) : USA. Herbert Irving Comprehensive Cancer Center. Columbia University. New York. NY. ; Maria ARGOS ; Joseph-H GRAZIANO ; Geoffrey-R HOWE ; Iftikhar HUSSAIN ; LEVY (Diane) : USA. Department of Biostatistics. Mailman School of Public Health. Columbia University. New York. NY. ; Hassina MOMOTAJ ; Faruque PARVEZ ; Vesna SLAVKOVICH ; Alexander VAN GEEN ; . YU CHEN ; Lydia ZABLOTSKA ; . ZHONGQI CHENG ; Columbia University. Lamont-Doherty Earth Observatory. New York. NY. USA ; Columbia University. Mailman School of Public Health. Department of Environmental Health Sciences. New York. NY. USA ; National Institute of Preventive and Social Medicine. Dhaka. BGD |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 163, n° 12, 2006) |
| Pagination : | 1138-1148 |
| Langues: | Anglais |
| Mots-clés : | Peau [pathologie] ; Arsenic ; Exposition ; Eau consommation humaine ; Facteur risque ; Santé environnementale ; Bengla Desh ; Asie ; Résultat ; Epidémiologie ; Homme |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 6R0xVB5n. Diffusion soumise à autorisation]. Millions of persons around the world are exposed to low doses of arsenic through drinking water. However, estimates of health effects associated with low-dose arsenic exposure have been extrapolated from high-dose studies. In Bangladesh, many persons have been exposed to a wide range of doses of arsenic from drinking water over a significant period of time. The authors evaluated dose-response relations between arsenic exposure from drinking water and premalignant skin lesions by using baseline data on 11,746 participants recruited in 2000-2002 for the Health Effects of Arsenic Longitudinal Study in Araihazar, Bangladesh. Several measures of arsenic exposure were estimated for each participant based on well-water arsenic concentration and usage pattern of the wells and on urinary arsenic concentration. In different regression models, consistent dose-response effects were observed for all arsenic exposure measures. Compared with drinking water containing<8.1 pg/liter of arsenic, drinking water containing 8.1-40.0,40.1-91.0,91.1-175.0, and 175.1-864.0 mug/liter of arsenic was associated with adjusted prevalence odds ratios of skin lesions of 1.91 (95% confidence interval (Cl) : 1.26,2.89), 3.03 (95% Cl : 2.05,4.50), 3.71 (95% Cl : 2.53,5.44), and 5.39 (95% Cl : 3.69,7.86), respectively. The effect seemed to be influenced by gender, age, and body mass index. These findings provide information that should be considered in future research and policy decisions. |
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