| Titre : | Exposure to Chlamydia pneumoniae infection and progression of age-related macular degeneration. (2005) |
| Auteurs : | Luba ROBMAN ; Gerald BYRNE ; Peter DIMITROV ; Robyn GUYMER ; Olaimatu MAHDI ; MCCARTY (Catherine) : USA. Marshfield Clinic Research Foundation. Marshfield. WI. ; MCNEIL (John) : AUS. Department of Epidemiology and Preventive Medicine. Monash University. Melbourne. ; Hugh TAYLOR ; Gabriella TIKELLIS ; University of Melbourne. Centre for Eye Research Australia. Melbourne. AUS ; University of Tennessee Health Science Center. Department of Molecular Sciences. Memphis. TN. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 161, n° 11, 2005) |
| Pagination : | 1013-1019 |
| Langues: | Anglais |
| Mots-clés : | Exposition ; Bactérie ; Infection ; Chlamydiose ; Bactériose ; Evolution ; Pronostic ; Pathologie ; Epidémiologie ; Personne âgée ; Homme ; Australie ; Océanie ; Oeil [pathologie] ; Rétinopathie |
| Résumé : | [BDSP. Notice produite par INIST-CNRS R0x0GIlo. Diffusion soumise à autorisation]. Recent studies have found an association between exposure to Chlamydia pneumoniae infection and risk of age-related macular degeneration (AMD). To assess a potential risk of AMD progression posed by exposure to C. pneumoniae, the authors reexamined Australian residents in 2001-2002 who were aged 51-89 years with early AMD at baseline (1992-1995). Examination included macular photography and an enzyme-linked immunosorbent assay to determine antibody titers to the elementary bodies from C. pneumoniae AR39. AMD progression was assessed quantitatively, using both coarse and fine progression steps following an international classification for AMD grading, and also qualitatively, by side-by-side comparison of baseline and follow-up macular photographs. Serologic data were available for 246 of 254 (97%) subjects. AMD progression was associated with a higher antibody titer. After adjustment for age, smoking, family history of AMD, history of cardiovascular diseases, and source study, the subjects in the uppertertiles of antibody titers were 2.1 (95% confidence interval : 0.92,4.69), 2.6 (95% confidence interval : 1.24,5.41), and 3.0 (95% confidence interval : 1.46,6.37) times more at risk of progression than those in the lowest tertile, using three definitions of progression, respectively. The fact that seroreactivity to C. pneumoniae was independently associated with the risk of AMD progression suggests that C. pneumoniae infection may be an additional risk factor for AMD progression. |
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