| Titre : | Childhood acute lymphoblastic leukemia and infections in the first year of life : A report from the United Kingdom childhood cancer study. (2007) |
| Auteurs : | E. ROMAN ; P. ANSELL ; J.M. BIRCH ; T. EDEN ; M. GREAVES ; S. KINSEY ; P.A. MCKINNEY ; C.D. MITCHELL ; J. SIMPSON |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 165, n° 5, 2007) |
| Pagination : | 496-504 |
| Langues: | Anglais |
| Mots-clés : | Infection ; Cancer ; Royaume Uni ; Europe ; Epidémiologie ; Nourrisson ; Homme |
| Résumé : | [BDSP. Notice produite par INIST-CNRS KFBR0xEL. Diffusion soumise à autorisation]. The United Kingdom Childhood Cancer Study was designed to examine the relation between childhood cancer and preceding exposure to infectious diseases. The authors analyzed the relation between diagnosis (1991-1996) of acute lymphoblastic leukemia (ALL) at ages 2-5 years and clinically diagnosed infections in infancy. Almost all study children (96% of both cases and controls) were taken to a general practitioner for a non-immunization-associated visit at least once before their first birthday. Children diagnosed with ALL had significantly more clinically diagnosed infectious episodes in infancy than did controls ; the average number of episodes was 3.6 (95% confidence interval (Cl) : 3.3,3.9) versus 3.1 (95% Cl : 2.9,3.2). This case-control difference was most apparent in the neonatal period (<=1 month) ; 18% of controls and 24% of ALL cases were diagnosed with at least one infection (odds ratio=1.4,95% Cl : 1.1,1.9 ; p<0.05). Cases who had more than one neonatal infectious episode tended to be diagnosed with ALL at a comparatively young age ; the mean age at ALL diagnosis was 37.7 months for cases with two or more episodes versus 45.3 months for cases with only one episode or none (p<0.01). These findings support the hypothesis that a dysregulated immune response to infection in the first few months of life promotes transition to overt ALL later in childhood. |
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