| Titre : | Vitamin K and Vitamin D Status : Associations with Inflammatory Markers in the Framingham Offspring Study. (2008) |
| Auteurs : | M. KYLA SHEA ; BENJAMIN (Emelia-J) : USA. Department of Epidemiology. School of Public Health. Boston University. Boston. MA. ; Sarah-L BOOTH ; Ralph-Bsr D'AGOSTINO ; Bess DAWSON-HUGHES ; Paul-F JACQUES ; Sekar KATHIRESAN ; John-Fjr KEANEY ; MASSARO (Joseph-M) : USA. Department of Biostatistics. School of Public Health. Boston University. Boston. MA. ; Christopher-J O'DONNELL ; Jose-M ORDOVAS ; Ramachandran-S VASAN ; Cardiology and Preventive Medicine Sections. Department of Medicine. School of Medicine. Boston University. Boston. MA. USA ; Department of Mathematics and Statistics. Boston University. Boston. MA. USA ; Department of Medicine. Massachusetts General Hospital. Harvard University. Boston. MA. USA ; Framingham Heart Study. National Heart. Lung. And Blood Institute. Framingham. MA. USA ; Jean Mayer Usda Human Nutrition Research Center on Aging. Tufts University. Boston. MA. USA ; Whitaker Cardiovascular Institute. Boston University Medical Center. Boston. MA. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 167, n° 3, 2008) |
| Pagination : | 313-320 |
| Langues: | Anglais |
| Mots-clés : | Vitamine D ; Vitamine K ; Association ; Inflammation ; Epidémiologie ; Famille descendante ; Homme |
| Résumé : | [BDSP. Notice produite par INIST-CNRS a2XzR0xF. Diffusion soumise à autorisation]. In vitro data suggest protective roles for vitamins K and D in inflammation. To examine associations between vitamins K and D and inflammation in vivo, the authors used multiple linear regression analyses, adjusted for age, sex, body mass index, triglyceride concentrations, use of aspirin, use of lipid-lowering medication, season, menopausal status, and hormone replacement therapy. Participants were from the Framingham Offspring Study (1997-2001 ; n=1,381 ; mean age=59 years ; 52% women). Vitamin K status, measured by plasma phylloquinone concentration and phylloquinone intake, was inversely associated with circulating inflammatory markers as a group and with several individual inflammatory biomarkers (p<0.01). Percentage of undercarboxylated osteocalcin, a functional measure of vitamin K status, was not associated with overall inflammation but was associated with C-reactive protein (p<0.01). Although plasma 25-hydroxyvitamin D was inversely associated with urinary isoprostane concentration, an indicator of oxidative stress (p<0.01), overall associations between vitamin D status and inflammation were inconsistent. The observation that high vitamin K status was associated with lower concentrations of inflammatory markers suggests that a possible protective role for vitamin K in inflammation merits further investigation. |
Service Documentation EHESP
Me connecter
PORTAIL DOCUMENTAIRE
École des hautes études en santé publique
Catalogue
Multi-bases
Accueil
Sélection de la langue
Adresse
Service Documentation EHESPBibliothèque Rennes Avenue du Professeur Léon Bernard – CS 74312 – 35043 Rennes Cedex Bibliothèque MSSH Paris 20 avenue George Sand - 93210 La Plaine Saint-Denis
France
Bibliothèque Rennes : 02 99 02 29 50 Bibliothèque MSSH Paris : 02 99 02 24 50
contact