| Titre : | Assessment of cumulative evidence on genetic associations : interim guidelines. Commentary. (2008) |
| Auteurs : | John-Pa IOANNIDIS ; David-J BALDING ; Paolo BOFFETTA ; Anand CHOKKALINGAM ; W. DANA FLANDERS ; Siobhan-M DOLAN ; Timothy-M FRAYLING, disc. ; Julian-Pt HIGGINS ; Muin-J KHOURY ; Julian LITTLE ; Mark-I MCCARTHY ; David-H MCDERMOTT ; Thomas-R O'BRIEN ; Grier-P PAGE ; Timothy-R REBBECK ; Daniela SEMINARA ; André-G UITTERLINDEN ; Paolo VINEIS ; Department of Epidemiology and Public Health. Imperial College. London. GBR |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 37, n° 1, 2008) |
| Pagination : | 120-135 |
| Langues: | Anglais |
| Mots-clés : | Méthode ; Epidémiologie ; Génétique ; Génome ; Facteur risque ; Pathologie ; Recommandation ; Homme |
| Résumé : | [BDSP. Notice produite par INIST-CNRS R0xNSqfj. Diffusion soumise à autorisation]. Established guidelines for causal inference in epidemiological studies may be inappropriate for genetic associations. A consensus process was used to develop guidance criteria for assessing cumulative epidemiologic evidence in genetic associations. A proposed semiquantitative index assigns three levels for the amount of evidence, extent of replication, and protection from bias, and also generates a composite assessment of'strong'moderate'or'weak'epidemiological credibility. In addition, we discuss how additional input and guidance can be derived from biological data. Future empirical research and consensus development are needed to develop an integrated model for combining epidemiological and biological evidence in the rapidly evolving field of investigation of genetic factors. |
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