| Titre : | Importance of familial factors in associations between offspring birth weight and parental risk of type-2 diabetes. Commentary. (2008) |
| Auteurs : | Niklas BERGVALL ; Sven CNATTINGIUS ; Anastasia ILIADOU ; Paul LICHTENSTEIN ; Anna LINDAM ; LINDSAY (Robert-S) / disc. : GBR. British Heart Foundation Glasgow Cardiovascular Research Centre. University of Glasgow. Glasgow. ; Yudi PAWITAN ; Department of Medical Epidemiology and Biostatistics. Karolinska Institutet. SWE |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 37, n° 1, 2008) |
| Pagination : | 185-193 |
| Langues: | Anglais |
| Mots-clés : | Poids naissance ; Famille descendante ; Facteur risque ; Epidémiologie ; Parent ; Jumeau ; Suède ; Homme ; Europe ; Glande endocrine [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST-CNRS oR0xBSTi. Diffusion soumise à autorisation]. Background It is hypothesized that associations found between birth weight and subsequent risk of type-2 diabetes are due to inherited genes affecting both fetal growth and metabolism of insulin. Methods To study whether there is a familial (shared environmental and genetic) link between birth weight and type-2 diabetes, the authors used a sample of 11411 Swedish like-sexed twins born from 1926 to 1958 with at least one offspring, to study the association between offspring birth weight for gestational age and parental risk of type-2 diabetes. Results Decreasing offspring birth weight for gestational age (with 1 SD) was associated with an increased risk of type-2 diabetes among father's [odds ratio (OR)=1.72,95% confidence interval (CI) : 1.33-2.23] and decreased risk among mothers (OR=0.43,95% CI : 0.30-0.62), independent of grand parental and parental socio-economic status and parental smoking. In paired twin analysis, the association between offspring birth weight and mothers with risk of type-2 diabetes was similar within-and between-twin pairs, whereas father's risk was slightly smaller within than between pairs (OR Between=1.90,95% CI : 1.10-3.28, and ORwithin=1.71,95% CI : 1.10-2.67, respectively). Conclusions The well-established association between paternal type-2 diabetes and offspring birth weight seems to primarily be due to as yet unidentified non-shared environmental factors. However, familial factors shared within twin pairs may contribute to the association. |
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