|
Résumé :
|
[BDSP. Notice produite par INIST-CNRS B9R0x3Vp. Diffusion soumise à autorisation]. The authors investigated the association between intrauterine growth and intellectual disability (ID). The appropriateness of intrauterine growth was assessed using percentage of optimal birth weight, a measure that accounts for gestational age, maternal height, parity, and infant sex. Using population-based record linkage, singleton Caucasian and Aboriginal children born in Western Australia in 1983-1992 and alive in 2002 with ID of unknown cause (n=2,625) were compared with children without ID (n=217,252). The odds of ID increased with less-than-optimal intrauterine growth. In Caucasian children, after adjustment for sociodemographic factors, severe growth restriction was associated with development of mild-moderate ID among preterm births (<37 weeks) (odds ratio (OR)=1.71,95% confidence interval (Cl) : 1.06,2.77) and term births (>37 weeks) (OR=2.42,95% Cl : 1.88,3.12) and with severe ID (OR=4.79,95% Cl : 2.59,8.83) among term births. Effects were similar among Aboriginal children. Severe growth restriction (OR=3.2,95% Cl : 1.3,7.9) and poor head growth (OR=3.6,95% Cl : 1.4,9.0) were independently associated with severe ID. Infants with excess intrauterine growth were more likely to be diagnosed with ID associated with autism spectrum disorder (OR=2.36,95% Cl : 0.93,6.03). These findings suggest that inappropriate intrauterine growth, less than or greater than optimal birth weight, is associated with development of ID.
|
