| Titre : | Early Life Growth and Hemostatic Factors : The Barry Caerphilly Growth Study. (2008) |
| Auteurs : | A. FRASER ; Y. BEN-SHLOMO ; DAVIES (D.) : GBR. Department of Child Health. University College of Wales. Cardiff Wales. ; R. HUGHES ; G.D.O. LOWE ; MCCARTHY (A.) : IRL. Health Research Board An Bord Taighde Sláinte. Dublin. ; A. RUMLEY ; Gdavey Smith ; K. TILLING ; Division of Cardiovascular and Medical Sciences. University of Glasgow. Glasgow. GBR |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 168, n° 2, 2008) |
| Pagination : | 179-187 |
| Langues: | Anglais |
| Mots-clés : | Croissance ; Développement staturopondéral ; Epidémiologie ; Homme ; Enzyme |
| Résumé : | [BDSP. Notice produite par INIST-CNRS JG78oR0x. Diffusion soumise à autorisation]. Associations between early life growth trajectories and a range of adult (aged - 25 years) hemostatic factors were assessed in the Barry Caerphilly Growth study (N=517) in South Wales, 1974-1999. Associations of birth weight, birth length, and weight and height velocities during three periods ("immediate" : 0-<5 months, "infant" : 5 months-<1 year 9 months, and "childhood" : 1 year 9 months-5 years) with adult levels of hemostatic factors were assessed. Birth weight was inversely associated with fibrinogen (bêta per 1-unit change in z score=-0.08,95% confidence interval (Cl) : - 0.15, - 0.02). Immediate weight velocity was inversely associated with factor VII (bêta=-1.88,95% Cl : - 3.84,0.09), factor VIII (bêta=-2.58,95% Cl : - 4.07, - 0.45), and von Willebrand factor antigen (bêta=-4.07,95% Cl : - 7.25, - 0.89). Birth length was inversely associated with fibrinogen (bêta=-0.07,95% Cl : - 0.14, - 0.01). Evidence was weaker for an inverse association of immediate height velocity with factor VIII (bêta=-2.16,95% Cl : - 4.62,0.29) and von Willebrand factor antigen (bêta=-2.85,95% Cl : - 6.52,0.81). Childhood height velocity was positively associated with D-dimer (ratio of geometric means=1.11,95% Cl : 1.01,1.23). Results support the view that the immediate postnatal period may be particularly important, possibly through impaired liver development and/or infection in early life, in determining cardiovascular disease risk. |
Service Documentation EHESP
Me connecter
PORTAIL DOCUMENTAIRE
École des hautes études en santé publique
Catalogue
Multi-bases
Accueil
Sélection de la langue
Adresse
Service Documentation EHESPBibliothèque Rennes Avenue du Professeur Léon Bernard – CS 74312 – 35043 Rennes Cedex Bibliothèque MSSH Paris 20 avenue George Sand - 93210 La Plaine Saint-Denis
France
Bibliothèque Rennes : 02 99 02 29 50 Bibliothèque MSSH Paris : 02 99 02 24 50
contact