| Titre : | Space-time clustering of glioma cannot be attributed to specific histological subgroups. (2006) |
| Auteurs : | M.P.W.A. HOUBEN ; J.M. BIRCH ; COEBERGH (J.W.W.) : NLD. Comprehensive Cancer Centre South. Eindhoven. ; MCNALLY (R.J.Q.) : GBR. School of Clinical Medical Sciences (Child Health) and School of Population and Health Sciences. University of Newcastle Upon Tyne. Newcastle. ; C.C. TIJSSEN ; C.M. VAN DUIJN ; DepartmErasmus Mc. ent of Epidemiology and Biostatistics. Rotterdam. NLD ; Royal Manchester Children's Hospital. Cancer Research Uk Paediatric and Familial Cancer Research Group. Manchester. GBR ; St Elisabeth Hospital. Department of Neurology. Tilburg. NLD |
| Type de document : | Article |
| Dans : | European journal of epidemiology (vol. 21, n° 3, 2006) |
| Pagination : | 197-201 |
| Langues: | Anglais |
| Mots-clés : | Infection ; Etiologie ; Europe ; Homme ; Epidémiologie ; Système nerveux [pathologie] ; Tumeur ; Pays Bas |
| Résumé : | [BDSP. Notice produite par INIST-CNRS NUR0xK13. Diffusion soumise à autorisation]. We previously showed that infectious exposures may be involved in the aetiology of adult glioma, by analysing for space-time clustering using population-based data from the South of the Netherlands. Here we extended these analyses and describe in detail the space-time clustering patterns in glioma subgroups, gender and age-categories. Knox tests for space-time interactions between cases were applied with fixed thresholds of close in space,<5 km, and close in time,<1 year apart. We used the spatial coordinates of the addresses at diagnosis in the analyses. Tests were repeated replacing geographical distance with distance to the Nth nearest neighbour. N was chosen such that the mean distance was 5 km. Data were also analysed by a second order procedure based on K-functions. There was only statistically significant space-time clustering for oligodendroglioma. Clustering was present for adults aged 30-54 years and was more pronounced among males. Given the low prior probability of an infectious aetiology for this specific subgroup, these results should probably be interpreted as false-positive. We conclude that space-time clustering of glioma cannot be attributed to a specific glioma subgroup. The observed clustering in our previous study is therefore probably an overall effect within and between glioma subgroups. |
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