| Titre : | Genetic variation in the sodium-dependent vitamin C transporters, SLC23A1, and SLC23A2 and risk for preterm delivery. (2006) |
| Auteurs : | Hans-Christian ERICHSEN ; Stephen-J CHANOCK ; Peter-K ECK ; Mark LEVINE ; Stephanie-A MULHERIN ENGEL ; Andrew-F OLSHAN ; Anna-Maria SIEGA-RIZ ; Robert WELCH ; Meredith YEAGER ; National Cancer Institute. Center for Cancer Research. Pediatric Oncology Branch. Section on Genomic Variation. Bethesda. MD. USA ; National Cancer Institute. Division of Cancer Epidemiology and Genetics. Advanced Technology Center. Core Genotyping Facility. Bethesda. MD. USA ; National Institutes of Health. National Institute of Diabetes and Digestive and Kidney Diseases. Molecular and Clinical Nutrition Section. Bethesda. MD. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 163, n° 3, 2006) |
| Pagination : | 245-254 |
| Langues: | Anglais |
| Mots-clés : | Génétique ; Sodium ; Vitamine C ; Facteur risque ; Prématurité ; Homme ; Femme ; Grossesse ; Epidémiologie ; Vitamine ; Gestation [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST-CNRS WxE0R0xz. Diffusion soumise à autorisation]. Vitamin C has been the focus of epidemiologic investigation in preterm delivery (<37 weeks'gestation), which is a leading cause of neonatal mortality and birth-related morbidity. There are two sodium-dependent membrane transporters encoded by SLC23A1 and SLC23A2, which have key roles in human vitamin C metabolism and which control dietary uptake, reabsorption, and tissue distribution of vitamin C. Using maternal DNA, the authors evaluated common single-nucleotide polymorphisms (SNPs) in SLC23A1 and SLC23A2 in a nested case-control analysis of the Pregnancy, Infection, and Nutrition Study (1995-2000) cohort. Of the associations observed for both haplotypes in SLC23A 1 and individual SNPs in SLC23A2, the most robust finding is with an intron 2 variant in SLC23A2. Heterozygotes and homozygotes for this variant had a 1.7-fold (95% confidence interval : 0.9,3.3) and a 2.7-fold (95% confidence interval : 1.2,6.3) elevation in the risk of spontaneous preterm birth, respectively. Semi-Bayesian hierarchical regression analysis, which simultaneously adjusted for multiple SNPs within the same gene, gave comparable results. The authors'findings link genetic variants in the vitamin C transporters to spontaneous preterm birth, which may explain previous dietary associations. If the findings from this study are confirmed, they may serve as the foundation for genetic risk assessment of nutritional pathways in preterm birth. |
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