| Titre : | Inflammation and triglycerides partially mediate the effect of prepregnancy body mass index on the risk of preeclampsia. (2005) |
| Auteurs : | Lisa-M BODNAR ; Gail-F HARGER ; NESS (Roberta-B) : USA. Department of Medicine. School of Medicine. University of Pittsburgh. Pittsburgh. PA. ; James-M ROBERTS ; Magee-Women's Research Institute. Pittsburgh. PA. USA ; University of Pittsburgh. School of Medicine. Department of Obstetrics Gynecology and Reproductive Sciences. Pittsburgh. PA. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 162, n° 12, 2005) |
| Pagination : | 1198-1206 |
| Langues: | Anglais |
| Mots-clés : | Inflammation ; Triglycéride ; Facteur risque ; Obésité ; Femme ; Homme ; Epidémiologie ; Gestation [pathologie] ; Lipide ; Toxémie gravidique ; Maladie nutrition |
| Résumé : | [BDSP. Notice produite par INIST-CNRS HfuR0xpb. Diffusion soumise à autorisation]. The objective of this study was to quantify the mediating role of inflammation and triglycerides in the association between prepregnancy body mass index (weight (kg)/height (m) 2) and preeclampsia. The authors conducted a nested case-control study of 55 preeclamptic women and 165 pregnant controls from the Pregnancy Exposures and Preeclampsia Prevention Study (Pittsburgh, Pennsylvania, 1997-2001). Serum samples collected at<20 weeks'gestation were analyzed for levels of C-reactive protein and triglycerides. The adjusted odds ratio (AOR) from a multivariable conditional logistic regression model assessing the total effect of body mass index on preeclampsia risk was compared with the AOR from the same model after results were controlled for C-reactive protein, triglycerides, and confounding factors (direct-effects model). The percentage of the total effect that was mediated through inflammation and triglycerides was calculated as 100 - [In (direct-effects AOR)/ln (total-effects AOR) ]. In the total-effects model, 4-and 8-unit increases in body mass index were associated with 1.7-fold (95% confidence interval (Cl) : 1.3,2.3) and 2.9-fold (95% Cl : 1.6,5.2) increases in preeclampsia risk, whereas in the direct-effects model, these AORs were 1.4 (95% Cl : 1.0,1.9) and 2.0 (95% Cl : 1.0,3.8), respectively. Inflammation was a more important mediator than triglycerides. These findings suggest that approximately one third of the total effect of body mass index on preeclampsia risk is mediated through inflammation and triglyceride levels. |
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