| Titre : | Immune-related conditions and immune-modulating medications as risk factors for non-Hodgkin's lymphoma : A case-control study. (2005) |
| Auteurs : | Eric-A ENGELS ; James-R CERHAN ; Joanne-S COLT ; Wendy COZEN ; Scoff DAVIS ; Gloria GRIDLEY ; Patricia HARTGE ; Martha-S LINET ; Richard-K SEVERSON ; Us Department of Health and Human Services. National Cancer Institute. Division of Cancer Epidemiology and Genetics. Rockville. MD. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 162, n° 12, 2005) |
| Pagination : | 1153-1161 |
| Langues: | Anglais |
| Mots-clés : | Médicament ; Thérapeutique médicamenteuse ; Chimiothérapie ; Thérapeutique ; Facteur risque ; Enquête cas témoin ; Epidémiologie ; Maladie autoimmune ; Transplantation organe ; Immunité ; Immunosuppresseur ; Etats Unis ; Amérique ; Homme ; Chimiothérapie anticancéreuse ; Médicament anticancéreux ; Immunopathologie ; Thérapeutique chirurgicale ; Chirurgie ; Greffe ; Oeil [pathologie] ; Stomatologie ; Amérique du Nord |
| Résumé : | [BDSP. Notice produite par INIST-CNRS vahbR0xZ. Diffusion soumise à autorisation]. In immunosuppressed or autoimmune disease states, disordered immune responses may lead to non-Hodgkin's lymphoma (NHL). In a US population-based case-control study of NHL (1998-2000), the authors collected personal histories of immune-related conditions and use of immune-modulating therapies as well as family histories of autoimmune conditions. The study included 1,321 NHL cases and 1,057 controls ; only half received some questionnaire components. NHL was associated with Sjögren's syndrome (odds ratio (OR)=13,95% confidence interval (Cl) : 1.7,100) and lupus (OR=4.2,95% Cl : 1.2,15). Two specific NHL subtypes were strongly associated with Sjögren's syndrome : salivary gland (OR=290,95% Cl : 33,2600) and marginal zone (OR=75,95% Cl : 9.1,610). NHL was less convincingly associated with receipt of an organ transplant (OR=2.0,95% Cl : 0.4,11). Other autoimmune conditions were too rare to evaluate or not associated with NHL. Corticosteroid use was unrelated to NHL (OR=1.0,95% Cl : 0.8,1.2), but methotrexate use was marginally associated (OR=2.3,95% Cl : 0.7,7.5). Family history of dermatomyositis was associated with NHL (7 cases vs. 0 controls, OR=infinite ; two-sided p=0.02), but dermatomyositis was absent in cases themselves. Family history of remaining conditions was unrelated to NHL. Results suggest that disordered immunity in some immune-related conditions can lead to NHL. |
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