| Titre : | Homocysteine and cognitive performance in the Framingham offspring study : Age is important. (2005) |
| Auteurs : | Merrill-F ELIAS ; Rhoda AU ; Alexa BEISER ; Ralph-B D'AGOSTINO ; Penelope-K ELIAS ; Paul-F JACQUES ; Jacob SELHUB ; Sudha SESHADRI ; Lisa M. Sullivan ; Philip-A WOLF ; Boston University School of Medicine. Department of Neurology. Boston. MA. USA ; Boston University. Department of Mathematics and Statistics. Statistics and Consulting Unit. Boston. MA. USA ; Tufts University. Jean Mayer Us Department of Agriculture Human Nutrition Research Center on Aging. Boston. MA. USA ; University of Maine. Department of Psychology. Orono. ME. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 162, n° 7, 2005) |
| Pagination : | 644-653 |
| Langues: | Anglais |
| Mots-clés : | Fonction cognitive ; Performance ; Trouble mémoire ; Epidémiologie ; Famille descendante ; Age ; Vieillissement ; Facteur risque ; Vitamine B |
| Résumé : | [BDSP. Notice produite par INIST-CNRS f0N6R0xe. Diffusion soumise à autorisation]. Plasma total homocysteine (tHcy) concentrations are associated with deficits in cognitive performance in persons free from dementia. The extent to which age modifies these associations is in need of further investigation in large, community-based, prospective studies combining the following elements : 1) multiple cognitive tests ; 2) statistical adjustment for the role of the vitamin cofactors folate, vitamin B6, and vitamin B12 ; and 3) adjustment for the presence of risk factors for cardiovascular disease and stroke. Using data collected between 1991 and 2002, the authors investigated the associations between tHcy and multiple measures of cognitive performance in 2,096 dementia-and stroke-free participants of the Framingham Offspring Study, who were stratified into three age groups (40-49 years, 50-59 years, 60-82 years), after findings of statistically significant tHcy-by-age interactions for multiple cognitive measures. Regardless of statistical adjustment for age, sex, gender, the vitamin cofactors, and cardiovascular risk factors, statistically significant inverse associations between tHcy and multiple cognitive domains were observed for individuals aged 60 or more years ; no such associations were observed for participants aged less than 60 years. Early preventive interventions may be important, because the inverse association between tHcy and cognitive performance is observed beyond middle age. |
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