| Titre : | Predictors of the Timing of Natural Menopause in the Multiethnic Cohort Study. (2008) |
| Auteurs : | Katherine DELELLIS HENDERSON ; Leslie BERNSTEIN ; Brian HENDERSON ; KOLONEL (Laurence) : USA. Cancer Research Center of Hawaii. University of Hawaii. Honolulu. HI. ; Malcolm-C PIKE ; Department of Cancer Etiology. City of Hope National Medical Center. Duarte. CA. USA ; Norris Comprehensive Cancer Center. Keck School of Medicine. University of Southern California. Los Angeles. CA. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 167, n° 11, 2008) |
| Pagination : | 1287-1294 |
| Langues: | Anglais |
| Mots-clés : | Ménopause ; Homme ; Femme ; Ethnie ; Population ; Epidémiologie ; Amérique ; Amérique du Nord |
| Résumé : | [BDSP. Notice produite par INIST-CNRS R0xkp77o. Diffusion soumise à autorisation]. The timing of natural menopause has implications for several health endpoints ; in particular, it is a risk factor for breast cancer. The authors investigated factors influencing the timing of natural menopause among 95,704 women with a mean age of 59.7 years (1 Oth-90th percentile range, 47.0-71.0) in five racial/ethnic groups in the Multiethnic Cohort Study, including non-Latina Whites, Japanese Americans, African Americans, Native Hawai'ians, and Latinas. The authors investigated whether race/ethnicity and several lifestyle and reproductive characteristics were associated with the timing of natural menopause. Race/ethnicity was a significant independent predictor of the timing of natural menopause. Other factors, including smoking, age at menarche, parity, and body mass index, did not significantly alter the race/ethnicity-specific hazard ratios. Relative to non-Latina Whites, natural menopause occurred earlier among Latinas (US-born Latinas : hazard ratio (HR)=1.10,95% confidence interval (Cl) : 1.07,1.14 ; non-US-born Latinas : HR=1.25,95% Cl : 1.21,1.30) and later among Japanese Americans (HR=0.93,95% Cl : 0.90,0.95). These results support the hypothesis that the timing of natural menopause is driven by a combination of genetic, reproductive, and lifestyle factors. |
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