| Titre : | The Tulane University School of Public Health and Tropical Medicine 100th Anniversary Issue. Physical Activity Reduces Salt Sensitivity of Blood Pressure : The Genetic Epidemiology Network of Salt Sensitivity Study. (2012) |
| Auteurs : | Casey-M REBHOLZ ; Lydia-A BAZZANO ; Pierre BUEKENS ; Ji-Chun CHEN ; . DEPEI LIU ; . DONGFENG GU ; . DONGSHENG HU ; . FANGHONG LU ; Jian-Feng HUANG ; . JIANG HE ; . JIANJUN MU ; . JIANXIN LI ; . JIE CAO ; . JING CHEN ; . JIXIANG MA ; . XU JI ; Cardiovascular Institute and Fuwai Hospital. Chinese Academy of Medical Sciences and Peking Union Medical College. And National Center for Cardiovascular Disease. Beijing. CHN ; Department of Medicine. School of Medicine. Tulane University. New Orleans. LA. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 176, n° 7, 2012) |
| Pagination : | S106-S113 |
| Langues: | Anglais |
| Mots-clés : | Activité physique ; Sel ; Sensibilité ; Pression artérielle ; Génétique ; Epidémiologie ; Réseau ; Régime alimentaire ; Alimentation ; Aliment ; Sodium |
| Résumé : | [BDSP. Notice produite par INIST-CNRS nnnqR0xk. Diffusion soumise à autorisation]. Salt sensitivity of blood pressure (BP) is influenced by genetic and environmental factors. A dietary feeding study was conducted from October 2003 to July 2005 that included a 7-day low-sodium intervention (51.3 mmol sodium/day) followed by a 7-day high-sodium intervention (307.8 mmol sodium/day) among 1,906 individuals who were 16 years of age or older and living in rural northern China. Salt sensitivity of BP was defined as mean BP change from the low-sodium intervention to the high-sodium intervention. Usual physical activity during the past 12 months was assessed at baseline using a standard questionnaire. The multivariable-adjusted means of systolic BP responses to high-sodium intervention were 5.21 mm Hg (95% confidence interval (CI) : 4.55,5.88), 4.97 mm Hg (95% CI : 4.35,5.59), 5.02 mm Hg (95% CI : 4.38,5.67), and 3.96 mm Hg (95% CI : 3.29,4.63) among participants from the lowest to the highest quartiles of physical activity, respectively (P=0.003 for linear trend). The multivariable-adjusted odds ratio of high salt sensitivity of systolic BP was 0.66 (95% CI : 0.49,0.88) for persons in the highest quartile of physical activity compared with those in the lowest quartile. Physical activity is significantly, independently, and inversely related to salt sensitivity of BP and may be particularly effective in lowering BP among salt-sensitive individuals. |
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