| Titre : | Benzodiazepine use and risk of dementia : evidence from the Caerphilly Prospective Study (CaPS). (2012) |
| Auteurs : | John GALLACHER ; BAYER (Antony) : GBR. Department of Geriatric Medicine. Cardiff University. Cardiff. ; BEN-SHLOMO (Yoav) : GBR. School of Social and Community Medicine. University of Bristol. ; Peter ELWOOD ; FISH (Mark) : GBR. Department of Neurology. Musgrove Park Hospital. Taunton Somerset. ; Janet PICKERING ; Department of Primary Care and Public Health. Cardiff University. Cardiff. GBR |
| Type de document : | Article |
| Dans : | Journal of epidemiology and community health (vol. 66, n° 10, 2012) |
| Pagination : | 869-873 |
| Langues: | Anglais |
| Mots-clés : | Démence ; Utilisation ; Facteur risque ; Risque ; Pays de Galles ; Etude prospective ; Grande Bretagne ; Europe ; Maladie dégénérative |
| Résumé : | [BDSP. Notice produite par INIST-CNRS JoItFR0x. Diffusion soumise à autorisation]. Background Benzodiazepine use is widespread in older people, although its benefit is uncertain. Aim To investigate the long-term effect of benzodiazepine use upon dementia risk. Methods A prospective cohort of men seen on five occasions over 22 years with full medication histories, repeat measures of cognitive function and a clinical diagnosis of dementia. Results Of 1134 men with complete data, 103 (9.1%) had been taking benzodiazepines regularly at one or more phases. These men showed a marked increased incidence of dementia (OR=3.50,95% CI 1.57 to 7.79, p=0.002), which persisted despite adjustment for psychological distress and other covariates. Men exposed in earlier phases showed a greater association than more recent exposure, counter to what one would expect if this was due to reverse causation, though we failed to demonstrate a dose-response effect with drug duration. Conclusion The taking of benzodiazepines is associated with an increased risk of dementia. |
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