| Titre : | Alcohol drinking and overall and cause-specific mortality in China : nationally representative prospective study of 220000 men with 15 years of follow-up. (2012) |
| Auteurs : | . LING YANG ; . GONGHUAN YANG ; . LIJUN WANG ; . MAIGENG ZHOU ; Iona MILLWOOD ; Richard PETO ; Paul SHERLIKER ; Margaret Smith ; . YUE CAI ; . YUEHUA HU ; . ZHENGMING CHEN ; Clinical Trial Service Unit and Epidemiological Studies Unit. (C.T.S.U.). University of Oxford. Oxford. GBR |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 41, n° 4, 2012) |
| Pagination : | 1101-1113 |
| Langues: | Anglais |
| Mots-clés : | Cancer ; Boisson alcoolisée ; Consommation alcool ; Consommation ; Facteur ; Homme ; Mortalité ; Epidémiologie ; Chine ; Etude prospective ; Alcool ; Asie |
| Résumé : | [BDSP. Notice produite par INIST-CNRS H8AR0xmt. Diffusion soumise à autorisation]. Background Regular alcohol drinking contributes both favourably and adversely to health in the Western populations, but its effects on overall and cause-specific mortality in China are still poorly understood. Methods A nationally representative prospective cohort study included 220 000 men aged 40-79 years from 45 areas in China in 1990-91, and>40 000 deaths occurred during 15 years of follow-up. Cox regression was used to relate alcohol drinking to overall and cause-specific mortality, adjusting for age, area, smoking and education. Results Overall, 33% of the participants reported drinking alcohol regularly at baseline, consuming mainly distilled spirits, with an estimated mean amount consumed of 372 g/week (46.5 units per week). After excluding all men with prior disease at baseline and the first 3 years of follow-up, there was a 5% [95% confidence interval (CI) 2-8] excess risk of overall mortality among regular drinkers. Compared with non-drinkers, the adjusted hazard ratios among men who drank<140,140-279,280-419,420-699 and>=700 g/week were 0.97,1.00,1.02,1.12 and 1.27, respectively (P<0.0001 for trend). The strength of the relationship appeared to be greater in smokers than in non-smokers. There was a strong positive association of alcohol drinking with mortality from stroke, oesophageal cancer, liver cirrhosis or accidental causes, a weak J-shaped association with mortality from ischaemic heart disease, stomach cancer and lung cancer and no apparent relationship with respiratory disease mortality. Conclusion Among Chinese men aged 40-79 years, regular alcohol drinking was associated with a small but definite excess risk of overall mortality, especially among smokers. |
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