Résumé :
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[BDSP. Notice produite par INIST-CNRS R0xmsGHl. Diffusion soumise à autorisation]. Background Osteoprotegerin (OPG) is a cytokine essential for the regulation of bone resorption, but large longitudinal studies on its relationship to fracture risk in humans are lacking. In this population-based study of 2740 men and 2857 post-menopausal women, it was examined whether serum OPG was associated with hip fracture incidence. The participants were followed for 15 years. Methods Baseline measurements included height, weight and serum OPG, and information about lifestyle, prevalent diseases and use of medication. Results Men with OPG in the highest quartile were 2.79-fold [95% confidence interval (CI) 1.34-5.82] more likely to have a hip fracture during follow-up, compared with those with OPG in the lowest quartile (P-trend over OPG quartiles
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