| Titre : | Breast Cancer Risk Factors Defined by Estrogen and Progesterone Receptor Status : The Multiethnic Cohort Study. (2009) |
| Auteurs : | Veronica-Wendy SETIAWAN ; Brian-E HENDERSON ; Laurence-N KOLONEL ; Kristine-R MONROE ; Malcolm-C PIKE ; Lynne-R WILKENS |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 169, n° 10, 2009) |
| Pagination : | 1251-1259 |
| Langues: | Anglais |
| Mots-clés : | Cancer ; Sein ; Facteur risque ; Ethnie ; Epidémiologie ; Homme |
| Résumé : | [BDSP. Notice produite par INIST-CNRS R0xDDCsG. Diffusion soumise à autorisation]. Prospective data on ethnic differences in hormone receptor-defined subtypes of breast cancer and their risk factor profiles are scarce. The authors examined the joint distributions of estrogen receptor (ER) and progesterone receptor (PR) status across 5 ethnic groups and the associations of established risk factors with ER/PR status in the Multiethnic Cohort Study (Hawaii and Los Angeles, California). During an average of 10.4 years of follow-up of 84,427 women between 1993-1996 and 2004/2005,2,543 breast cancer cases with data on ER/PR status were identified : 1,672 estrogen receptor-positive (ER+)/progesterone receptor-positive (PR+) ; 303 ER+/progesterone receptor-negative (PR-) ; 77 estrogen receptor-negative (ER-)/PR+and 491 ER-/PR-ER/PR status varied significantly across racial/ethnic groups even within the same tumor stage (for localized tumors, P<0.0001 ; for advanced tumors, P=0.01). The highest fraction of ER-/PR-tumors was observed in African Americans (31%), followed by Latinas (25%), Whites (18%), Japanese (14%), and Native Hawaiians (14%). Associations differed between ER+/PR+and ER-/PR-cases for postmenopausal obesity (P=0.02), age at menarche (P=0.05), age at first birth (P=0.04), and postmenopausal hormone use (P<0.0001). African Americans are more likely to be diagnosed with ER-/PR-tumors independently of stage at diagnosis, and there are disparate risk factor profiles across the ER/PR subtypes of breast cancer. |
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