| Titre : | Age at Last Birth in Relation to Risk of Endometrial Cancer : Pooled Analysis in the Epidemiology of Endometrial Cancer Consortium. (2012) |
| Auteurs : | Veronica WENDY SETIAWAN ; Kristin ANDERSON ; Leslie BERNSTEIN ; Louise-A BRINTON ; James-R CERHAN ; . CHU CHEN ; Wendy COZEN ; Immaculata DE VIVO ; Sandra-L DEMING ; Jennifer DOHERTY ; Jo-L FREUDENHEIM ; Marc-T GOODMAN ; Susan-E HANKINSON ; Pamela-L Horn-Ross ; . HUI CAI ; Stalo KARAGEORGI ; James-Vjr LACEY ; . LINGENG LU ; Jolanta LISSOWSKA ; Galina LURIE ; Thomas MACK ; Rayna-K MATSUNO ; Susan MCCANN ; Kirsten-B MOYSICH ; Sara-H OLSON ; Malcolm-C PIKE ; Radhai RASTOGI ; Timothy-R REBBECK ; Harvey RISCH ; Kim ROBIEN ; Catherine SCHAIRER ; Xiao-Ou SHU ; Amanda-B SPURDLE ; Brian-L STROM ; Pamela-J THOMPSON ; Giske URSIN ; Penelope-M WEBB ; Noel-S Weiss ; Nicolas WENTZENSEN ; Yong-Bing XIANG ; . XIAOLIN LIANG ; Hannah-P YANG ; Herbert YU ; Australian National Endometrial Cancer Study Group. AUS ; Beckman Research Institute of City of Hope. Duarte. CA. USA ; Center for Clinical Epidemiology and Biostatistics. University of Pennsylvania School of Medicine. Philadelphia. PA. USA ; Department of Cancer Prevention and Control. Roswell Park Cancer Institute. Buffalo. NY. USA ; Division of Genetics and Population Health. Queensland Institute of Medical Research. Brisbane. AUS ; Epidemiology and Biostatistics. Memorial Sloan-Kettering Cancer Center. New York. NY. USA ; M Sklodowska-Curie Memorial Cancer Center and Institute of Oncology. Warsaw Poland. USA ; School of Public Health. University of Minnesota. Minneapolis. MN. USA ; University of Hawaii Cancer Center. Honolulu. HI. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 176, n° 4, 2012) |
| Pagination : | 269-278 |
| Langues: | Anglais |
| Mots-clés : | Cancer ; Age ; Naissance ; Facteur risque ; Risque ; Epidémiologie ; Endomètre ; Parité ; Reproduction ; Historique ; Histoire |
| Résumé : | [BDSP. Notice produite par INIST-CNRS HAp8R0x8. Diffusion soumise à autorisation]. Childbearing at an older age has been associated with a lower risk of endometrial cancer, but whether the association is independent of the number of births or other factors remains unclear. Individual-level data from 4 cohort and 13 case-control studies in the Epidemiology of Endometrial Cancer Consortium were pooled. A total of 8,671 cases of endometrial cancer and 16,562 controls were included in the analysis. After adjustment for known risk factors, endometrial cancer risk declined with increasing age at last birth (Ptrend<0.0001). The pooled odds ratio per 5-year increase in age at last birth was 0.87 (95% confidence interval : 0.85,0.90). Women who last gave birth at 40 years of age or older had a 44% decreased risk compared with women who had their last birth under the age of 25 years (95% confidence interval : 47,66). The protective association was similar across the different age-at-diagnosis groups and for the 2 major tumor histologic subtypes (type I and type II). No effect modification was observed by body mass index, parity, or exogenous hormone use. In this large pooled analysis, late age at last birth was independently associated with a reduced risk of endometrial cancer, and the reduced risk persisted for many years. |
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