| Titre : | Gender aspects on heart failure incidence and mortality in a middle-aged, urban, community-based population sample : the Malmö preventive project. (2009) |
| Auteurs : | TASEVSKA-DINEVSKA (G.) : SWE. Lund University. Department of Cardiology. University Hospital Malmö. Malmö. ; L.M.A. KENNEDY ; P.M. NILSSON ; WILLENHEIMER (R.) : SWE. Lund University and Heart Health Group. Malmö. ; Lund University. Department of Clinical Sciences. Medicine. University Hospital Malmö. Malmö. SWE |
| Type de document : | Article |
| Dans : | European journal of epidemiology (vol. 24, n° 5, 2009) |
| Pagination : | 249-257 |
| Langues: | Anglais |
| Mots-clés : | Insuffisance cardiaque ; Sexe ; Incidence ; Mortalité ; Morbidité [épidémiologie] ; Epidémiologie ; Milieu urbain ; Communauté ; Population ; Suède ; Prévention santé ; Morbidité ; Homme ; Europe ; Cardiopathie |
| Résumé : | [BDSP. Notice produite par INIST-CNRS DFqB8R0x. Diffusion soumise à autorisation]. There is little epidemiological data on heart failure (HF) in the younger age groups dominating clinical HF trials. We assessed gender-specific long-term HF incidence and mortality in an urban community-based sample of middle-aged subjects. Between 1974 and 1992,33,342 HF-free subjects (10,900 [32.7% ] women, mean age 45.7 9+/-7.4 years) were included in the Malmö Preventive Project, on average 21.7+/-4.3 years before study end. Patients hospitalised for or dying of HF were categorised as HF patients, and 120 (1.1%) women versus 644 (2.9%) men experienced HF : 6.0 vs. 12.3 cases per 10,000 person years ; hazard ratio [HR] 0.61,95% confidence interval [CI] 0.50-0.74, P<0.0001. Among all subjects, women compared with men had lower all-cause (49.3 vs. 84.0 cases per 10,000 person years ; HR 0.68,95% CI 0.64-0.73, P<0.0001) and HF-related (2.6 vs. 7.4 cases per 10,000 person years ; HR 0.50,95% CI 0.37-0.67, P<0.0001) mortality risk. Female and male HF patients had similar age-adjusted mortality risk : 1,314 vs. 1,602 cases per 10,000 patient years ; HR 0.78,95% CI 0.58-1.07, P=0.12. Among HF patients, 55.3% of deaths in women and 40.6% in men were non-cardiovascular, and only 7.9% deaths were due to HF. In conclusion : In a middle-aged, urban, community-based sample, women had lower risk of HF, all-cause death and HF-related death over two decades of follow-up. Female and male HF patients had similar mortality risk after the diagnosis of HF. In these comparatively young HF patients, few deaths were due to HF and more than 4 out of 10 deaths were non - cardiovascular. |
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