| Titre : | Vascular Function, Inflammation, and Variations in Cardiac Autonomic Responses to Particulate Matter Among Welders. (2009) |
| Auteurs : | Shona-C FANG ; Jennifer-M CAVALLARI ; CHEN (Jiu-Chiuan) : USA. Department of Epidemiology. University of North Carolina at Chapel Hill School of Public Health. Chapel Hill. NC. ; CHRISTIANI (David-C) : USA. Department of Medicine. Massachusetts General Hospital. Boston. MA. ; Ellen-A EISEN ; MITTLEMAN (Murray-A) : USA. Cardiovascular Epidemiology Research Unit. Beth Israel Deaconess Medical Center. Boston. MA. |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 169, n° 7, 2009) |
| Pagination : | 848-856 |
| Langues: | Anglais |
| Mots-clés : | Vaisseau ; Inflammation ; Coeur ; Augmentation ; Pathologie ; Sensibilité ; Epidémiologie ; Homme ; Appareil cardiovasculaire ; Fréquence cardiaque |
| Résumé : | [BDSP. Notice produite par INIST-CNRS R0xAnqBG. Diffusion soumise à autorisation]. Patients with health conditions associated with impaired vascular function and inflammation may be more susceptible to the adverse health effects of fine particulate (particulate matter with a mass median aerodynamic diameter of<2.5 mum (PM2.5)) exposure. In 2006, the authors conducted a panel study to investigate directly whether vascular function and inflammation (assessed by C-reactive protein) modify PM2.5-associated reductions in heart rate variability among 23 young male workers (mean age, 40 years) from Massachusetts. Concurrent 24-hour ambulatory electrocardiogram and personal PM2.5 exposure information was collected over a total of 36 person-days, including either or both welding and nonwelding days. Linear mixed models were used to examine the 5-minute standard deviation of normal-to-normal intervals (SDNN) in relation to the moving PM2.5 averages in the preceding 1-4 hours. C-reactive protein levels and 3 measures of vascular function (augmentation index, mean arterial pressure, and pulse pressure) were determined at baseline. The authors observed an inverse association between the 1-hour PM2.5 and 5-minute SDNN. Greater SDNN declines were observed among those with C-reactive protein (Pinteraction<0.001) and augmentation index (P=0.06) values at or above the 75th percentile and pulse pressure values below the 75th percentile (P<0.001). Systemic inflammation and poorer vascular function appear to aggravate particle-related declines in heart rate variability among workers. |
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