| Titre : | Cancer Risk After Exposure to Treatments for Ovulation Induction. (2009) |
| Auteurs : | CALDERON-MARGALIT (R.) : ISR. Braun School of Public Health and Community Medicine. Hadassah-Hebrew University. Jerusalem. ; Y. FRIEDLANDER ; S. HARLAP ; K. KLEINHAUS ; O. MANOR ; O. PALTIEL ; M.C. Perrin ; R. YANETZ |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 169, n° 3, 2009) |
| Pagination : | 365-375 |
| Langues: | Anglais |
| Mots-clés : | Cancer ; Facteur risque ; Risque ; Exposition ; Thérapeutique ; Incidence ; Ovaire ; Utérus ; Epidémiologie ; Homme ; Appareil génital femelle |
| Résumé : | [BDSP. Notice produite par INIST-CNRS tR0xDIGF. Diffusion soumise à autorisation]. Uncertainty continues as to whether treatments for ovulation induction are associated with increased risk of cancer. The authors conducted a long-term population-based historical cohort study of parous women. A total of 15,030 women in the Jerusalem Perinatal Study who gave birth in 1974-1976 participated in a postpartum survey. Cancer incidence through 2004 was analyzed using Cox's proportional hazards models, controlling for age and other covariates. Women who used drugs to induce ovulation (n=567) had increased risks of cancer at any site (multivariate hazard ratio (HR)=1.36,95% confidence interval (Cl) : 1.06,1.74). An increased risk of uterine cancer was found among women treated with ovulation-inducing agents (HR=3.39,95% Cl : 1.28,8.97), specifically clomiphene (HR=4.56,95% Cl : 1.56,13.34). No association was noted between use of ovulation-inducing agents and ovarian cancer (age-adjusted HR=0.61,95% Cl : 0.08,4.42). Ovulation induction was associated with a borderline-significant increased risk of breast cancer (multivariate HR=1.42,95% Cl : 0.99,2.05). Increased risks were also observed for malignant melanoma and non-Hodgkin lymphoma. These associations appeared stronger among women who waited more than 1 year to conceive. Additional follow-up studies assessing these associations by drug type, dosage, and duration are needed. |
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