| Titre : | Arsenic Exposure During Pregnancy and Size at Birth : A Prospective Cohort Study in Bangladesh. (2009) |
| Auteurs : | RAHMAN (Anisur) : SWE. International Maternal and Child Health. Department of Women's and Children's Health. Uppsala University. University Hospital. Uppsala. ; Eva-Charlotte EKSTROM ; Shams EL ARIFEEN ; Barbro NERMELL ; Lars-Ake PERSSON ; Allan-H Smith ; Marie VAHTER ; Mohammed YUNUS |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 169, n° 3, 2009) |
| Pagination : | 304-312 |
| Langues: | Anglais |
| Mots-clés : | Arsenic ; Exposition ; Femme ; Homme ; Femme enceinte ; Grossesse ; Taille corporelle ; Etude prospective ; Poids naissance ; Mère ; Urine ; Epidémiologie ; Nouveau né ; Asie |
| Résumé : | [BDSP. Notice produite par INIST-CNRS JmHnR0xs. Diffusion soumise à autorisation]. The authors evaluated the association of prenatal arsenic exposure with size at birth (birth weight, birth length, head and chest circumferences). This prospective cohort study, based on 1,578 mother-infant pairs, was conducted in Matlab, Bangladesh, in 2002-2003. Arsenic exposure was assessed by analysis of arsenic in urine collected at around gestational weeks 8 and 30. The association of arsenic exposure with size at birth was assessed by linear regression analyses. In analysis over the full range of exposure (6-978 mug/L), no dose-effect association was found with birth size. However, significant negative dose effects were found with birth weight and head and chest circumferences at a low level of arsenic exposure (<100 mug/L in urine). In this range of exposure, birth weight decreased by 1.68 (standard error (SE), 0.62) g for each 1-mug/L increase of arsenic in urine. For head and chest circumferences, the corresponding reductions were 0.05 (SE, 0.03) mm and 0.14 (SE, 0.03) mm per 1 mug/L, respectively. No further negative effects were shown at higher levels of arsenic exposure. The indicated negative effect on birth size at a low level of arsenic exposure warrants further investigation. |
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