| Titre : | Combined Effects of Complement Factor H Genotypes, Fish Consumption, and Inflammatory Markers on Long-Term Risk for Age-related Macular Degeneration in a Cohort. (2009) |
| Auteurs : | JIE JIN WANG (.) : AUS. Retinal Vascular Imaging Centre. Centre for Eye Research Australia. Department of Ophthalmology. University of Melbourne. Melbourne Victoria. ; Sudha IYENGAR ; Tripti JOSHI ; Ronald Klein ; Barbara-Ek Klein ; Paul MITCHELL ; Elena ROCHTCHINA ; Theru-A SIVAKUMARAN ; Wayne Smith ; Centre for Vision Research. Department of Ophthalmology. Westmead Millennium Institute. University of Sydney. Sydney New South Wales. AUS |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 169, n° 5, 2009) |
| Pagination : | 633-641 |
| Langues: | Anglais |
| Mots-clés : | Tabagisme ; Poisson ; Consommation alimentaire ; Inflammation ; Marqueur tabagisme ; Long terme ; Facteur risque ; Risque ; Santé environnementale ; Environnement ; Génétique ; Tabac ; Epidémiologie ; Homme ; Rétinopathie |
| Résumé : | [BDSP. Notice produite par INIST-CNRS kR0xtml7. Diffusion soumise à autorisation]. At baseline in 1992-1994, the authors assessed the combined effects of complement factor H (CFH) genotypes with smoking, fish consumption, and inflammatory markers on the risk of age-related macular degeneration (AMD) in 3,654 persons aged>49 years. They reexamined 75% of the survivors after 5 and 10 years, confirming incident AMD by side-by-side photographic grading. Of the 2,452 persons followed in the Blue Mountains Eye Study, 1,881 were genotyped (rs1061170), with CC, CT, and TT identified in 13.6%, 46.7%, and 39.7%, respectively. AMD risk increased with each additional C allele (early AMD : age-and sex-adjusted relative risk (RR)=1.6,95% confidence interval (Cl) : 1.2,1.9 ; late AMD : RR=2.3,95% Cl : 1.5,3.6). Late AMD risk among current smokers with the CC/CT genotypes (RR=10.7,95% Cl : 3.4,33.9) was 5-fold that for genotypically similar nonsmokers (RR=2.2,95% Cl : 0.9,5.5) versus current nonsmokers with TT genotypes. Weekly compared with less than weekly consumption of fish was associated with reduced late AMD risk in participants with the CC genotype (RR=0.15,95% Cl : 0.03,0.8) but not the CT (RR=0.7,95% Cl : 0.3,2.0) or TT (RR=1.3,95% Cl : 0.2,7.2) genotypes. This study documents joint contributions from genetic and systemic factors in determining the progression of AMD. |
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