| Titre : | Elevated depressive symptoms and compositional changes in LDL particles in middle-aged men. (2010) |
| Auteurs : | LEHTO (Soili-M) : FIN. Kuopio Psychiatric Centre. Kuopio. ; KAPLAN (George-A) : USA. Center for Social Epidemiology and Population Health. The University of Michigan School of Public Health. Ann Arbor. MI. ; Jussi KAUHANEN ; NISKANEN (Leo) : FIN. Department of Medicine. Kuopio University Hospital. Kuopio. ; Anu RUUSUNEN ; Tommi TOLMUNEN ; Heimo VIINAMAKI ; Sari VOUTILAINEN ; Department of Psychiatry. Kuopio University Hospital. Kuopio. FIN |
| Type de document : | Article |
| Dans : | European journal of epidemiology (vol. 25, n° 6, 2010) |
| Pagination : | 403-409 |
| Langues: | Anglais |
| Mots-clés : | Etat dépressif ; Changement ; Hypercholestérolémie ; Homme ; Epidémiologie ; Lipide ; Hyperlipoprotéinémie |
| Résumé : | [BDSP. Notice produite par INIST-CNRS R0xIrAp8. Diffusion soumise à autorisation]. Depression and cardiovascular disease (CVD) are closely associated, but the mechanisms underlying this connection are unclear. Regardless of the low cholesterol levels observed in depression, a small particle size of low-density lipoproteins (LDL), as well as elevated apolipoprotein B (ApoB) levels, are related to increased CVD risk, even when levels of LDL cholesterol are low. We examined the association between elevated depressive symptoms and compositional changes in serum LDL particles in a sample of 2,456 middle-aged Finnish men. Depressive symptoms were assessed with the 18-item Human Population Laboratory Depression Scale, and the study population was divided into two groups (elevated depressive symptoms, n=269 ; non-depressed, n=2,187). The levels of serum total cholesterol (TC), low-and high-density lipoprotein cholesterol (LDL-C, HDL-C), triglycerides (TG), and ApoB were determined. The LDL-C/ApoB ratio, a marker of compositional changes in LDL particle size, was calculated. The group with elevated depressive symptoms had lowered levels of serum TC (P=0.028) and LDL-C (P=0.008). No differences were observed in the LDL-C/ApoB ratio. The likelihood for belonging to the group with elevated depressive symptoms increased 10% for each 0.5 mmol/l decrease in the levels of TC (P=0.002) or LDL-C (P=0.001) in regression models adjusted for age, examination years, marital and socioeconomic status, energy expenditure, body mass index, CVD history, alcohol consumption, smoking, and the use of lipid-lowering, antidepressant and antipsychotic medications. Our findings suggest that greater small-particle LDL levels are not associated with depression, and are thus unlikely to underlie the association between cardiovascular risk and depression. |
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