| Titre : | Body mass index and mortality : results of a cohort of 184,697 adults in Austria. (2009) |
| Auteurs : | Jochen KLENK ; Hans CONCIN ; Glinter DIEM ; Gabriele NAGEL ; RAPP (Kilian) : DEU. Department of Clinical Gerontology. Robert-Bosch-Hospital. Stuttgart. ; Alexander STRASAK ; Hano ULMER ; Agency for Preventive and Social Medicine. Bregenz. ATR ; Department of Medical Statistics. Informatics and Health Economics. Medical University of Innsbruck. Innsbruck. ATR ; Institute of Epidemiology. University of Ulm. Ulm. DEU ; Vhm & Pp Study Group. INC |
| Type de document : | Article |
| Dans : | European journal of epidemiology (vol. 24, n° 2, 2009) |
| Pagination : | 83-91 |
| Langues: | Anglais |
| Mots-clés : | Mortalité ; Epidémiologie ; Résultat ; Adulte ; Autriche ; Homme ; Europe |
| Résumé : | [BDSP. Notice produite par INIST-CNRS trm9R0x9. Diffusion soumise à autorisation]. There is still a debate about the role of body mass index (BMI) as a risk factor for all-cause mortality. Most investigations with large sample sizes focused on populations from the United States, studies from Central-European cohorts are not available. We investigated the association between BMI and all-cause mortality and cause-specific mortality within a cohort in Austria. Design of this article is "Cohort study". The Subjects used were 184,697 men and women (mean age 41.7+/-15.4 years). Weight and height were measured. Cox proportional hazards models were used to estimate hazard ratios (HR). During a median follow-up of 15.1 years 15,557 deaths (6,077 from cardiovascular disease, 4,443 from cancer and 606 from respiratory disease) were seen. A U-shaped association between BMI and all-cause mortality was observed in men and women. Compared with the reference category (BMI 22.5-24.9 kg/m2) high risks were found both in the highest category of BMI (>=35 kg/m2) with HR of 2.13 (95% CI, 1.82-2.48) in men and 1.60 (95% CI, 1.42-1.81) in women and in the lowest category (<18.5 kg/m2) with HR of 2.57 (95% CI, 2.17-3.05) in men and 1.40 (95% CI, 1.21-1.62) in women. Similar patterns were seen among ever-smokers and non-smokers. Increased mortality with increasing BMI was driven by cardiovascular diseases and to a lesser extent by cancers. Respiratory diseases contributed to mortality in the lowest BMI category independently from smoking status. Underweight and obesity were both associated with higher all-cause mortality in men and women. |
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