Titre : | Is it exposure to cigarette smoke or to smokers which increases the risk of meningococcal disease in teenagers ? (2006) |
Auteurs : | Pietro-G COEN ; ASHBY (Deborah) : GBR. Centre for Environmental Preventive Medicine. Queen Mary's Barts and the London School of Medicine and Dentistry. University of London. ; Robert BOOY ; STUART (James-M) : GBR. Health Protection Agency South West. The Wheelhouse. Bonds Mill. Stonehouse Gloucestershire. ; Joanna TULLY ; VINER (Russell-M) : GBR. Department of Paediatrics. Royal Free and University College Medical School. University College London. ; University of London. Royal London Hospital. Academic Department of Child Health. Queen Mary. GBR |
Type de document : | Article |
Dans : | International journal of epidemiology (vol. 35, n° 2, 2006) |
Pagination : | 330-336 |
Langues: | Anglais |
Mots-clés : | Méningite ; Bactériose ; Infection ; Facteur risque ; Septicémie ; Epidémiologie ; Tabagisme passif ; Enquête cas témoin ; Angleterre ; Grande Bretagne ; Royaume Uni ; Europe ; Adolescent ; Homme ; Système nerveux [pathologie] ; Fumée tabac |
Résumé : | [BDSP. Notice produite par INIST-CNRS DR0xCtQl. Diffusion soumise à autorisation]. Background : Passive smoking appears to increase the risk of meningococcal disease (MD) in adolescents. Whether this effect is attributable to exposure to cigarette smoke or contact with smokers is unknown. Methods : We conducted a prospective population-based case-control study with age, sex matched-controls in 1 : 1 matching. Participants were 15-19 year old with MD recruited at hospital admission in six regions (65% of the population of England) from January 1999 through June 2000, and their matched controls. Data on potential risk factors were gathered by confidential interview, including seven passive smoking variables. Factor analysis was performed to assess the dimensionality of the passive smoking exposure variables. The data were analysed with univariate and multivariate conditional logistic regression. Results : 144 case-control pairs were recruited (51% male ; median age 17.6). Factor analysis identified two independent factors representing passive smoking (P |