| Titre : | Impact of occupational carcinogens on lung cancer risk in a general population. (2012) |
| Auteurs : | Sara DE MATTEIS ; Pier-Alberto BERTAZZI ; Neil-E CAPORASO ; Dario CONSONNI ; Hans KROMHOUT ; Jay-H LUBIN ; Angela-C PESATORI ; Susan Peters ; Maria TERESA LANDI ; Margaret TUCKER ; Roel-Ch VERMEULEN ; Sholom WACHOLDER ; Division of Cancer Epidemiology and Genetics. National Cancer Institute. Nih. Bethesda. MD. USA ; Institute for Risk Assessment Sciences. Environmental Epidemiology Division. Utrecht University. Utrecht. NLD ; Unit of Epidemiology. Department of Preventive Medicine. Fondazione Irccs Ca'Granda Ospedale Maggiore Policlinico and Epoca Research Centre. Department of Occupational and Environmental Health. Università degli Studi di Milano. Milan. ITA |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 41, n° 3, 2012) |
| Pagination : | 711-721 |
| Langues: | Anglais |
| Mots-clés : | Exposition professionnelle ; Risque ; Carcinogène ; Homme ; Enquête cas témoin ; Epidémiologie ; Cancer |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 9CmR0xr9. Diffusion soumise à autorisation]. Background Exposure to occupational carcinogens is an important preventable cause of lung cancer. Most of the previous studies were in highly exposed industrial cohorts. Our aim was to quantify lung cancer burden attributable to occupational carcinogens in a general population. Methods We applied a new job-exposure matrix (JEM) to translate lifetime work histories, collected by personal interview and coded into standard job titles, into never, low and high exposure levels for six known/suspected occupational lung carcinogens in the Environment and Genetics in Lung cancer Etiology (EAGLE) population-based case-control study, conducted in Lombardy region, Italy, in 2002-05. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated in men (1537 cases and 1617 controls), by logistic regression adjusted for potential confounders, including smoking and co-exposure to JEM carcinogens. The population attributable fraction (PAF) was estimated as impact measure. Results Men showed an increased lung cancer risk even at low exposure to asbestos (OR : 1.76 ; 95% CI : 1.42-2.18), crystalline silica (OR : 1.31 ; 95% CI : 1.00-1.71) and nickel-chromium (OR : 1.18 ; 95% CI : 0.90-1.53) ; risk increased with exposure level. For polycyclic aromatic hydrocarbons, an increased risk (OR : 1.64 ; 95% CI : 0.99-2.70) was found only for high exposures. The PAFs for any exposure to asbestos, silica and nickel-chromium were 18.1,5.7 and 7.0%, respectively, equivalent to an overall PAF of 22.5% (95% CI : 14.1-30.0). This corresponds to about 1016 (95% CI : 637-1355) male lung cancer cases/year in Lombardy. Conclusions These findings support the substantial role of selected occupational carcinogens on lung cancer burden, even at low exposures, in a general population. |
Service Documentation EHESP
Me connecter
PORTAIL DOCUMENTAIRE
École des hautes études en santé publique
Catalogue
Multi-bases
Accueil
Sélection de la langue
Adresse
Service Documentation EHESPBibliothèque Rennes Avenue du Professeur Léon Bernard – CS 74312 – 35043 Rennes Cedex Bibliothèque MSSH Paris 20 avenue George Sand - 93210 La Plaine Saint-Denis
France
Bibliothèque Rennes : 02 99 02 29 50 Bibliothèque MSSH Paris : 02 99 02 24 50
contact