| Titre : | Sex difference and the role of leptin in the association between high-sensitivity C-reactive protein and adiposity in two different populations. (2012) |
| Auteurs : | Isabelle-Anne ROSSI ; Murielle BOCHUD ; BOVET (Pascal) : SYC. Ministry of Health. Victoria. ; Fred PACCAUD ; Patrick TAFFE ; Peter VOLLENWEIDER ; Gérard WAEBER ; Department of Medicine. Internal Medicine. Lausanne University Hospital. Lausanne. CHE ; Institute of Social and Preventive Medicine. (I.U.M.S.P.). Lausanne University Hospital and University of Lausanne. Epalinges. CHE |
| Type de document : | Article |
| Dans : | European journal of epidemiology (vol. 27, n° 5, 2012) |
| Pagination : | 379-384 |
| Langues: | Anglais |
| Mots-clés : | Obésité ; Sexe ; Femme ; Etude comparée ; Homme ; Association ; Sensibilité ; Tissu adipeux ; Population ; Afrique ; Epidémiologie |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 8m8ER0xm. Diffusion soumise à autorisation]. Elevated high-sensitivity C-reactive protein (hs-CRP) concentration is associated with an increased risk of cardiovascular disease but this association seems to be largely mediated via conventional cardiovascular risk factors. In particular, the association between hs-CRP and obesity has been extensively demonstrated and correlations are stronger in women than men. We used fractional polynomials-a method that allows flexible modeling of non linear relations-to investigate the dose/response mathematical relationship between hs-CRP and several indicators of adiposity in Caucasians (Switzerland) and Africans (Seychelles) surveyed in two population-based studies. This relationship was non-linear exhibiting a steeper slope for low levels of hs-CRP and a higher level in women. The observed sex difference in the relationship between hs-CRP and adiposity almost disappeared upon adjustment for leptin, suggesting that these sex differences might be partially mediated, by leptin. All these relationship were similar in Caucasians and Africans. This is the first report on a non-linear relation, stratified by gender, between hs-CRP and adiposity. |
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