| Titre : | Prospective Study of Restless Legs Syndrome and Risk of Depression in Women. (2012) |
| Auteurs : | . YANPING LI ; ASCHERIO (Alberto) : USA. Department of Epidemiology. Harvard School of Public Health. Boston. MA. ; IFEOMA OKEREKE (Olivia) : USA. Department of Psychiatry. Brigham and Women's Hospital and Harvard Medical School. Boston. MA. ; Atul MALHOTRA ; Fariba MIRZAEI ; Eilis-J O'REILLY ; John WINKELMAN ; . XIANG GAO ; Division of Sleep Medicine. Department of Medicine. Brigham and Women's Hospital and Harvard Medical School. Boston. MA. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 176, n° 4, 2012) |
| Pagination : | 279-288 |
| Langues: | Anglais |
| Mots-clés : | Etat dépressif ; Etude prospective ; Facteur risque ; Risque ; Femme ; Epidémiologie ; Homme |
| Résumé : | [BDSP. Notice produite par INIST-CNRS R0xIls8G. Diffusion soumise à autorisation]. Most research on the association between restless legs syndrome (RLS) and depression has involved cross-sectional data. The objective of the present study was to evaluate this issue prospectively among Nurses'Health Study participants. A total of 56,399 women (mean age=68 years) who were free of depression symptoms at baseline (2002) were followed until 2008. Physician-diagnosed RLS was self-reported. During 300,155 person-years of follow-up, the authors identified 1,268 incident cases of clinical depression (regular use of antidepressant medication and physician-diagnosed depression). Women with RLS at baseline were more likely to develop clinical depression (multivariate-adjusted relative risk (RR)=1.5,95% confidence interval (CI) : 1.1,2.1 ; P=0.02) than those without RLS. The presence of RLS at baseline was also associated with higher scores on the 10-item Center for Epidemiologic Studies Depression Scale (CESD-10) and the 15-item Geriatric Depression Scale (GDS-15) thereafter. Multivariable-adjusted mean differences were 1.00 (standard error, 0.12) for CESD-10 score and 0.47 (standard error, 0.07) for GDS-15 score between women with RLS and those without RLS (P<0.0001). In conclusion, women with physician-diagnosed RLS had an increased risk of developing clinical depression and clinically relevant depression symptoms. Further prospective studies using refined approaches to ascertainment of RLS and depression are warranted. |
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