Titre : | Serum Omega-6 Polyunsaturated Fatty Acids and the Metabolic Syndrome : A Longitudinal Population-based Cohort Study. (2012) |
Auteurs : | Mauno VANHALA ; ALA-KORPELA (Mika) : FIN. Institute of Clinical Medicine. Department of Internal Medicine. Biocenter Oulu and Clinical Research Center. University of Oulu. Oulu. ; Antti-J KANGAS ; Hannu KAUTIAINEN ; MANTYSELKA (Pekka) : FIN. Unit of Primary Health Care. University of Eastern Finland and Kuopio University Hospital. Kuopio. ; SALTEVO (Juha) : FIN. Department of Medicine. Central Finland Central Hospital. Jyvaskyla. ; Pasi SOININEN ; Computational Medicine Research Group. Institute of Clinical Medicine. Faculty of Medicine. University of Oulu and Biocenter Oulu. Oulu. FIN ; Nmr Metabonomics Laboratory. Department of Biosciences. University of Eastern Finland. Kuopio. FIN ; Unit of General Practice. Central Finland Central Hospital. Jyväskylä. FIN |
Type de document : | Article |
Dans : | American journal of epidemiology (vol. 176, n° 3, 2012) |
Pagination : | 253-260 |
Langues: | Anglais |
Mots-clés : | Sérum ; Epidémiologie ; Population ; Acide gras ; Finlande ; Europe ; Glande endocrine [pathologie] |
Résumé : | [BDSP. Notice produite par INIST-CNRS mqR0xJD9. Diffusion soumise à autorisation]. The serum fatty acid composition reflects the dietary fatty acid composition from the past few days to several weeks. However, the role of serum omega-3 (from fish and fish oils) and omega-6 (from vegetable oils) polyunsaturated fatty acids (PUFAs) in the course of metabolic syndrome is poorly understood. At the Primary Health Care Unit in Pieksamaki, Finland, all subjects born in 1942,1947,1952,1957, and 1962 (n=1,294) were invited for health checkups in 1997-1998 and 2003-2004. Metabolic syndrome was defined by using the new, harmonized criteria. The serum omega-3 PUFAs, omega-6 PUFAs, and total fatty acids were analyzed by proton nuclear magnetic resonance spectroscopy. Altogether, data from both checkups were available for 665 subjects. After adjustment for age, sex, and baseline body mass index, the incidence of metabolic syndrome between the 2 checkups with a 6.4-year follow-up was inversely associated (P |