| Titre : | Cross-Sectional and Prospective Cohort Study of Serum 25-Hydroxyvitamin D Level and Obesity in Adults The HUNT Study. (2012) |
| Auteurs : | Xiao-Mei MAI ; CAMARGO (Carlos-Ajr) : USA. Department of Emergency Medicine. Massachusetts General Hospital. Harvard Medical School. Boston. MA. ; Arnulf LANGHAMMER ; YUE CHEN (.) : CAN. Department of Epidemiology and Community Medicine. Faculty of Medicine. University of Ottawa. Ottawa. ON. |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 175, n° 10, 2012) |
| Pagination : | 1029-1036 |
| Langues: | Anglais |
| Mots-clés : | Obésité ; Etude prospective ; Sérum ; Adulte ; Vitamine D ; Epidémiologie ; Homme |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 9oR0x9IC. Diffusion soumise à autorisation]. Experimental studies suggest that vitamin D modulates the activity of adipocytes. The authors examined baseline serum 25-hydroxyvitamin D (25 (OH) D) level in relation to prevalent and cumulative incident obesity in Norway. A cohort of 25,616 adults aged 19-55 years participated in both the second and third surveys of the Nord-Trondelag Health Study (HUNT 2 (1995-1997) and HUNT 3 (2006-2008)). Serum 25 (OH) D levels measured at baseline and anthropometric measurements taken at both baseline and follow-up were available for a random sample of 2,460 subjects. Overall, 40% of the 2,460 subjects had a serum 25 (OH) D level less than 50.0 nmol/L, and 37% had a level of 50.0-74.9 nmol/L. The prevalence and cumulative incidence of obesity, defined as body mass index (weight (kg)/height (m) 2)>30, were 12% and 15%, respectively. Lower serum 25 (OH) D level was associated with a higher prevalence of obesity. In the 2,165 subjects with baseline BMI less than 30, a serum 25 (OH) D level less than 50.0 nmol/L was associated with a significantly increased odds ratio for incident obesity during follow-up (adjusted odds ratio=1.73,95% confidence interval : 1.24,2.41). When prevalent and incident obesity were classified according to waist circumference (>88 cm for women,>=102 cm for men), similar results were obtained. In addition to prevalent obesity, a serum 25 (OH) D level less than 50.0 nmol/L was significantly associated with new-onset obesity in adults. |
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