Titre :
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Enrollment of racial/ethnic minorities in NIAID-funded networks of HIV vaccine trials in the United States, 1988 to 2002. (2005)
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Auteurs :
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Gaston DJOMAND ;
George-W COUNTS ;
Dante DITOMMASO ;
Michael-G HUDGENS ;
Joanna KATZMAN ;
Beryi-A KOBLIN ;
Patrick-S SULLIVAN ;
Hiv Vaccine Trials Network. Fred Hutchinson Cancer Research Center. Seattle. WA. USA
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Type de document :
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Article
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Dans :
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Public health reports (vol. 120, n° 5, 2005)
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Pagination :
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543-548
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Langues:
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Anglais
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Mots-clés :
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Race
;
Ethnie
;
Financement
;
Réseau
;
Homme
;
Sida
;
Virose
;
Infection
;
Vaccination
;
Essai thérapeutique
;
Etats Unis
;
Amérique
;
Immunopathologie
;
Amérique du Nord
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Résumé :
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[BDSP. Notice produite par INIST-CNRS xk0R0xhM. Diffusion soumise à autorisation]. Objective : The purpose of this study was to analyze enrollment of racial/ethnic minorities in Phase I and Phase II HIV vaccine trials in the U.S. conducted by National Institute of Allergy and Infectious Diseases (NIAID) - funded networks from 1988 to 2002. Methods : A centralized database was searched for all NIAID-funded networks of HIV vaccine trial enrollment data in the U.S. from 1988 through 2002. The authors reviewed data from Phase I or Phase II preventive HIV vaccine trials that included HIV-1 uninfected participants at low to moderate or high risk for HIV infection based on self-reported risk behaviors. Of 66 identified trials, 55 (52 Phase I, 3 Phase II) met selection criteria and were used for analyses. Investigators extracted data on participant demographics using statistical software. Results : A total of 3,731 volunteers enrolled in U.S. NIAID-funded network HIV vaccine trials from 1988 to 2002. Racial/ethnic minority participants represented 17% of the overall enrollment. By pooling data across all NIAID-funded networks from 1988 to 2002, the proportion of racial/ethnic minority participants was significantly greater (Fisher's exact test p-value
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