| Titre : | Estimation of the risk of transmission of hepatitis C between spouses in Egypt based on seroprevalence data : Nutritional epidemiology. (2005) |
| Auteurs : | Laurence-S MAGDER ; ABDEL-AZIZ (Fatma) : EGY. Center for Field and Applied Research. Qalubyia. ; Mohamed Abdel-Hamid ; Alan-D FIX ; MEDHAT (Ahmed) : EGY. Assiut University Faculty of Medicine. Assiut. ; MIKHAIL (Nabiel-Nh) : EGY. Assiut University Cancer Institute. Assiut. ; Mostafa-K MOHAMED ; Gthomas STRICKLAND ; National Hepatology and Tropical Medicine Research Institute. Cairo. EGY ; University of Maryland School of Medicine. Department of Epidemiology and Preventive Medicine. Baltimore. MD. USA |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 34, n° 1, 2005) |
| Pagination : | 160-165 |
| Langues: | Anglais |
| Mots-clés : | Hépatite virale C ; Virose ; Infection ; Prévalence ; Sérologie ; Facteur risque ; Epidémiologie ; Maladie sexuellement transmissible ; Conjoint ; Egypte ; Afrique ; Homme ; Appareil digestif [pathologie] ; Foie [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 0GP64R0x. Diffusion soumise à autorisation]. Background : Transmission of hepatitis C virus (HCV) between spouses could be due to sexual contact, sharing needles, or other routes. There is uncertainty regarding the degree to which HCV is transmitted between spouses. Methods : Data from a 1997 cross-sectional serological survey of HCV in two communities in Egypt were used to estimate the risk of transmission between spouses by simultaneously modelling the probabilities of community acquisition and spousal transmission of HCV as functions of known predictors. Results : We estimate that the probability of wife-to-husband transmission was 34% (95% CI : 15-49%) and 10% (95% CI : 0-26%) for anti-HCV-positive wives with and without detectable HCV RNA, respectively. The probability of husband-to-wife transmission was estimated to be 3% (95% CI : 0-13%) and 0% (95% CI : 0-9%) for husbands with and without detectable HCV RNA, respectively, at the time of the survey. There was moderate evidence that the probability of wife-to-husband transmission differed from that of husband-to-wife transmission (P=0.076), and there was greater risk of transmission from those with detectable RNA at the time of the survey (P=0.046). We estimate that 6% of those infected acquired HCV from their spouse. Conclusion : Our study results support the possibility that HCV is transmitted between spouses in Egypt. Further research is needed to identify the exact routes of transmission so that preventive measures can be instituted. |
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