| Titre : | Low birthweight and Type 2 diabetes : A study on 11 162 Swedish twins. Commentary : Genetic epidemiology. (2004) |
| Auteurs : | A. ILIADOU ; S. CNATTINGIUS ; P. LICHTENSTEIN ; PHILLIPS (D.I.W.) / disc. : GBR. Mrc Unit. Southampton General Hospital. Southampton. |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 33, n° 5, 2004) |
| Pagination : | 948-954 |
| Langues: | Anglais |
| Mots-clés : | Facteur risque ; Epidémiologie ; Jumeau ; Suède ; Europe ; Homme ; Gestation [pathologie] ; Prématurité ; Glande endocrine [pathologie] ; Métabolisme [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST-CNRS hOEdR0x9. Diffusion soumise à autorisation]. Background : To investigate the association between low birthweight and diabetes in a population-based Swedish twin sample. Method : A cohort of 11 162 same-sexed Swedish twins born between 1906 and 1958 was used in order to investigate the risk of developing Type 2 diabetes between and within twin pairs by utilizing random effects linear models. Results : Between pairs there was a significant increase in risk of developing Type 2 diabetes for a 1-kg increase in their mean birthweight (odds ratio [OR]=2.13 ; P<0.01), adjusted for age, sex, body mass index (BMI), and smoking status. The corresponding risk within pair was 2.03 (P=0.07) for monozygotic twins and 1.15 (P=0.7I) for dizygotic twins. The test of the heterogeneity of the within and between effects showed no significant difference between the estimates. Conclusions : The study suggests that reduced fetal growth increase the risk of Type 2 diabetes due to an in utero programming effect possibly caused by intrauterine malnutrition, However, it does not exclude the possibility of a common genetic mechanism. |
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