Résumé :
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[BDSP. Notice produite par INIST-CNRS 06YcR0xk. Diffusion soumise à autorisation]. Background : Pre-eclampsia shares a number of risk factors with cardiovascular disease (CVD). Women with recurrent pre-eclampsia or pre-eclampsia early in pregnancy reportedly have an increased long-term risk of CVD. Short stature is a risk factor for CVD but has rarely been examined in relation to pre-eclampsia. Methods : We used data from 59 968 singleton live births in the Danish National Birth Cohort born between 1998 and 2001 to assess risk of severe pre-eclampsia/eclampsia (296 cases) in relation to self-reported height. We examined the association in multiple logistic regressions stratified by parity. Results : Among primiparas there was a weak association (compared with women<165 cm, women>172 cm had on OR of 0.79,95% CI : 0.55,1.14). Among multiparas, the tallest women had an adjusted OR of 0.42 (95% CI : 0.20,0.87) of developing severe pre-eclampsia compared with women<165 cm. The OR per centimetre was 0.94 (95% CI : 0.91,0.97). Self-reported pre-existing hypertension did not explain this association, which also persisted when the analysis was restricted to non-overweight women. Conclusions : Short stature was associated with a higher risk of severe pre-eclampsia in multiparas participating in the Danish National Birth Cohort.
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