| Titre : | CTLA-4 gene polymorphisms and susceptibility to type 1 diabetes mellitus : A HuGE review and meta-analysis. (2005) |
| Auteurs : | Fotini-K KAVVOURA ; LOANNIDIS (John-Pa) : GRC. Biomedical Research Institute. Foundation for Research and Technology-Hellas. Ioannina. |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 162, n° 1, 2005) |
| Pagination : | 3-16 |
| Langues: | Anglais |
| Mots-clés : | Hérédité ; Maladie autoimmune ; Epidémiologie ; Gène ; Génétique ; Glande endocrine [pathologie] ; Immunopathologie |
| Résumé : | [BDSP. Notice produite par INIST-CNRS R0xSA87t. Diffusion soumise à autorisation]. The authors performed a meta-analysis of 33 studies examining the association of type 1 diabetes mellitus with polymorphisms in the cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) gene, including the A49G (29 comparisons), C (-318) T (three comparisons), and (AT) n microsatellite (six comparisons) polymorphisms. The studies included 5,637 cases of type 1 diabetes and 6,759 controls (4,775 and 5,829, respectively, for analysis of the A49G polymorphism). The random-effects odds ratio for the *G (Ala) allele versus the *A (Thr) allele was 1.45 (95% confidence interval (Cl) : 1.28,1.65), with significant between-study heterogeneity (p<0.001). The effect size tended to be higher in type 1 diabetes cases with age of onset<20 years (odds ratio (OR)=1.61), and there was a significant association between the presence of glutamic acid decarboxylase-65 autoantibodies and the * G allele among type 1 diabetes cases (OR=1.49). Larger studies showed more conservative results (p=0.011). After exclusion of studies with fewer than 150 subjects and studies with significant deviation from Hardy-Weinberg equilibrium in the controls, the summary odds ratio was 1.40 (95% Cl : 1.28,1.54). Available data showed no strong association for the 106-base-pair allele of the microsatellite polymorphism (OR=0.99,95% Cl : 0.64,1.55) or the *T allele of the C (-318) T polymorphism (OR=0.92,95% Cl : 0.45,1.89). This meta-analysis demonstrates that the CTLA-4*G genotype is associated with type 1 diabetes. |
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