Résumé :
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[BDSP. Notice produite par INIST-CNRS 8AOR0xd4. Diffusion soumise à autorisation]. Background : Low birth weight and subsequent rapid child growth are associated with later blood pressure levels. The role of maternal and child nutrition in this association remains unclear. Methods : We studied 450 men and women (ages 21-29 years) born during a randomized trial of protein-energy supplementation (Atole) vs low energy/no protein supplementation (Fresco) in pregnancy and early childhood in four rural Guatemalan villages from 1969 to 1977. Results : Protein-energy supplementation was not associated with differences in blood pressure in adulthood (diastolic blood pressure (DBP) : bêta=0.69 mm Hg, 95% confidence internal (CI) (-0.82-2.19) ; P=0.37 ; systolic blood pressure (SBP) : bêta=0.17 mm Hg, 95% CI (-1.68-2.02) ; P=0.86). Within the Atole group, maternal height was associated with later SBP (0.22 mm Hg/cm, 95% CI (-0.002-0.45) ; P=0.05). No other associations between maternal nutritional status, birth size, child growth, or supplement intake were observed for adult blood pressure. Conclusions : Our data do not support the role of maternal nutrition during pregnancy, birth size, or early child growth in programming adult blood pressure. Likewise, we found no effect of protein-energy supplementation in pregnancy or in early childhood on blood pressure in young adults.
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