| Titre : | Community epidemiology of Chlamydia and Mycoplasma pneumoniae in LRT1 in France over 29 months. (2005) |
| Auteurs : | GAILLAT (Jacques) : FRA. The Infectious Diseases Unit. Hôpital d'Annecy. ; Christiane BEBEAR ; Bertille DEBARBEYRAC ; Jean-Pierre DUCROIX ; Antoine Flahault ; MAYAUD (Charles) : FRA. The Pneumology Unit. Hôpital Tenon. Paris. ; Jeanne ORFILA ; PORTIER (Henri) : FRA. The Infectious Diseases Unit. Hôpital de Dijon. ; Hôpital Nord. Bacteriology Unit. Amiens. FRA ; Hôpital Pellegrin. Bacteriology Unit. Bordeaux. FRA |
| Type de document : | Article |
| Dans : | European journal of epidemiology (vol. 20, n° 7, 2005) |
| Pagination : | 643-651 |
| Langues: | Anglais |
| Mots-clés : | Bronchite ; Communauté ; Epidémiologie ; Pneumonie ; Bactérie ; Bactériose ; Infection ; France ; Europe ; Infection respiratoire aiguë ; Chlamydiose ; Homme ; Appareil respiratoire [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST-CNRS qh48DR0x. Diffusion soumise à autorisation]. Background : The role of Chlamydia pneumoniae (CP) and Mycoplasma pneumoniae (MP) in lower respiratory tract infections (LRTI) is still little known in community settings. Methods : In all, 3207 adult cases of LRTI (871 with pneumonia, and 2336 with acute bronchitis) were prospectively included in the ETIIC. ETIIC : ETude de l'Incidence des Infections respiratoires basses d'origine Communautaire dues à Chlamydia pneumoniae et Mycoplasma pneumoniae (Incidence of CP and MP in LRTI in community settings) program by 303 general practitioners and 24 hospital physicians in France between September 1997 and February 2000. The polymerase chain reaction and immunoassays were used to detect CP or MP in 3198 pharyngeal specimens obtained by gargling. Results : Of these 3198 patients, 232 (7.3%), were PCR-positive for CP and/or MP. Immunoassays were far less sensitive than PCRs (Se=2 and 13% for MP and CP). Among the 2336 patients with acute bronchitis, PCR was positive for CP in 95 (4.1%), and for MP, in 54 (2.3%). Among the 671 patients with radiologically confirmed pneumonia, PCR was positive for CP in 23 (3.4%), and for MP in 49 (7.3%). CP and MP displayed significant geographic heterogeneity. Independent clinical determinants of positive PCR for CP and/or MP were age below 45 years, previous antimicrobial therapy (especially betalactams). Clinical signs were not of practical use in distinguishing accurately between etiologic diagnoses. Conclusions : CP or MP diagnosed by PCR were found in more than 7% of patients with LRTI in community settings with a significant geographical heterogeneity and significant temporal trends in the incidence. |
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