Titre :
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A method for indirectly estimating gene-environment effect modification and power given only genotype frequency and odds ratio of environmental exposure. (2005)
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Auteurs :
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EFIRD (Jimmy-Thomas) : USA. John A Burns School of Medicine. University of Hawai'i at Manoa. Honolulu. HI.
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Type de document :
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Article
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Dans :
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European journal of epidemiology (vol. 20, n° 5, 2005)
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Pagination :
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389-393
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Langues:
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Anglais
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Mots-clés :
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Epidémiologie
;
Homme
;
Estimation
;
Gène
;
Génétique
;
Environnement
;
Modification
;
Fréquence
;
Exposition
;
Santé environnementale
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Résumé :
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[BDSP. Notice produite par INIST-CNRS 2NDR0xm4. Diffusion soumise à autorisation]. Both genes and environment are important determinants of disease. In this paper we model gene-environment effect modification on the odds ratio scale OR (GE/D) and show how to indirectly estimate the effect and 95% confidence intervals (CI) for the simple case of no main genetic and environmental effects [i.e., OR (GE/D)=OR (GE/D)=1]. A statistic is presented to test the null hypothesis OR (GE/D)=1 and to calculate corresponding power, given the odds ratio for environmental exposure OR (E/D) and population genotype frequency (g). Direct extension of the above model provides a mathematical framework for estimating confidence bounds in more complex cases involving partial genetic and/or environmental effects.
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