| Titre : | Enhanced Na-Li countertransport : a marker of inherited susceptibility to type 2 diabetes. (2005) |
| Auteurs : | Olga VACCARO ; CIRILLO (Massimo) : ITA. Nephrology. Second University. Naples Napoli. ; Vincenzo CUOMO ; LAURENZI (Martino) : ITA. Center of Epidemiological Research. Merck Sharp & Dohme. ; Mario MANCINI ; PANARELLI (Walter) : ITA. Gubbio Hospital. Gubbio. ; Gabriele RICCARDI ; TREVISAN (Maurizio) : USA. School of Public Health and Health Professions. University at Buffalo. Buffalo. NY. ; Federico 2 University of Naples. Department of Clinical and Experimental Medicine. Napoli. ITA ; Gubbio Study Research Group. INC |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 34, n° 5, 2005) |
| Pagination : | 1123-1128 |
| Langues: | Anglais |
| Mots-clés : | Hypertension artérielle ; Insuline ; Sensibilité ; Facteur risque ; Epidémiologie ; Italie ; Europe ; Homme ; Glande endocrine [pathologie] ; Métabolisme [pathologie] ; Appareil circulatoire [pathologie] ; Maladie héréditaire |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 2WcR0xsH. Diffusion soumise à autorisation]. Introduction : The association between type 2 diabetes and hypertension has long been described, but the mechanisms remain unclear. Na-Li countertransport (Na-Li CT) activity is viewed as a marker of inherited pre-disposition to hypertension, especially if associated with other metabolic abnormalities. Aim To evaluate whether enhanced Na-Li CT activity is a predictor of type 2 diabetes. METHODS : Study participants were 2167 men and women, 30-70 years. Na-Li CT activity, glucose, HDL cholesterol, blood pressure, height, and weight were measured. Six years incidence of diabetes (WHO) was assessed. RESULTS : Baseline Na-Li CT activity was significantly higher for people who developed diabetes at follow-up (n=101) than for those who remained non-diabetic (364+/-184 vs 300+/-150 micromol/l RBC/h, P<0.001). This finding was confirmed after correction for obesity, hypertension, and blood glucose. Six years'incidence of diabetes increased across tertiles of baseline Na-Li CT activity - from 2 to 7% - with a significant linear trend (P<0.001). In multivariate analyses Na-Li CT is a significant predictor of diabetes independent of age, BMI, HDL cholesterol, hypertension, and plasma glucose ; based on exponentiation of the regression coefficient Na-Li CT higher by 154 micromol (i.e. 1 SD of the population mean) was associated with a 36% greater risk of incident diabetes. CONCLUSIONS : Prospective data from the present study show for the first time enhanced Na-Li CT activity is a significant predictor of development of diabetes in adults, thus suggesting that it could be viewed as a pre-clinical, possibly genetic, marker of inherited susceptibility to type 2 diabetes. |
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