| Titre : | Risk of type 2 diabetes among HIV-infected and healthy subjects in Italy. (2012) |
| Auteurs : | Laura GALLI ; Alba BIGOLONI ; Antonella CASTAGNA ; Alberto GALLIANI ; Nicola GIANOTTI ; Monica GUFFANTI ; Hamid HASSON ; LAZZARIN (Adriano) : ITA. University Vita-Salute San Raffaele. Milan. ; Gabriele PELLICCIOTTA ; PIATTI (Piermarco) : ITA. Cardiometabolic and Clinical Trials Unit. Metabolic and Cardiovascular Division. Internal Medicine Department. San Raffaele Scientific Institute. Milan. ; Stefania SALPIETRO ; Infectious Diseases. San Raffaele Scientific Institute. Milan. ITA ; Occupational Health. H San Raffaele Resnati Spa. Milan. ITA |
| Type de document : | Article |
| Dans : | European journal of epidemiology (vol. 27, n° 8, 2012) |
| Pagination : | 657-665 |
| Langues: | Anglais |
| Mots-clés : | Facteur risque ; Risque ; Sida ; Italie ; VIH ; Surveillance ; Contrôle ; Prévalence ; Homme ; Epidémiologie ; Virose ; Infection ; Europe ; Rétrovirus ; Virus ; Glande endocrine [pathologie] ; Immunopathologie |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 8IB8nR0x. Diffusion soumise à autorisation]. Type 2 diabetes mellitus is a growing problem in HIV population and a comparison with the general population may help screening and prevention. In this cross-sectional study the authors determined the prevalence of type 2 diabetes mellitus in 4,249 HIV-infected subjects attending the San Raffaele Infectious Diseases Department compared with 9,148 healthy controls recruited in 15 Italian regions, and identified risk factors associated with of type 2 diabetes mellitus. Type 2 diabetes mellitus was defined as reported diabetes, a fasting plasma glucose concentration>=7.0 mmol/l, or current use of anti-diabetic medication. Prevalence of type 2 diabetes mellitus was higher in HIV-infected than healthy subjects (4.1 vs.2.5% ; P<0.0001). At multivariable analysis, HIV-infected subjects (odds ratio 1.70,95% CI, 1.12-2.51 ; P=0.009), older age (P<0.0001), higher BMI (P<0.0001) and hypertension (P=0.039) were associated with a higher risk of diabetes. Among HIV-infected patients, the risk of type 2 diabetes mellitus increased with older age (P<0.0001), higher BMI (P=0.003), higher triglycerides (P=0.015) lower total cholesterol (P=0.008), longer duration of HIV infection (P=0.036) lower nadir CD4 (P=0.027). Prevalence of type 2 diabetes mellitus in HIV-infected subjects was almost two-fold increased than healthy subjects and it was associated with the typical risk factors of the general population and also to longer duration of HIV infection and lower nadir CD4. |
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